Original ArticlesSignificance of Ground-glass Opacity on HRCT in Long-term Follow-up of Patients With Systemic SclerosisShah, Rosita M. MD*; Jimenez, Sergio MD†; Wechsler, Richard MD‡Author Information *Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 †Department of Rheumatology, Thomas Jefferson University Hospital, 233 S. 10th St ‡Department of Radiology, Thomas Jefferson University Hospital, 111 S. 11th St. Philadelphia, PA 19107 Reprints: Rosita M. Shah, MD, Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St Philadelphia, PA 19104 (e-mail: [email protected]). Journal of Thoracic Imaging: May 2007 - Volume 22 - Issue 2 - p 120-124 doi: 10.1097/01.rti.0000213572.16904.40 Buy Metrics Abstract Despite little supportive evidence, ground-glass opacity at high-resolution computed tomography, without other signs of fibrosis, has been equated with potentially reversible disease, and in systemic sclerosis, frequently prompts aggressive anti-inflammatory treatment to prevent pulmonary fibrosis. Our study evaluates ground-glass opacity on sequential high-resolution computed tomography in 41 patients with systemic sclerosis over a mean follow-up period of 27 months (r6 to 60 mo). Ground-glass opacity was the most common imaging finding, present in 66%, and usually associated with other signs of interstitial disease, including nonfibrotic interstitial opacities in 27% and fibrotic interstitial opacities in 32%. Improvement was only documented in 2(5%) patients with ground glass and nonfibrotic interstitial opacities. In systemic sclerosis, ground-glass opacity is most commonly associated with irreversible disease. Disease progression or improvement could not be predicted by the presence of ground-glass opacity. © 2007 Lippincott Williams & Wilkins, Inc.