Case Report-PulmonaryPulmonary Alveolar Proteinosis and End-Stage Pulmonary Fibrosis A Rare AssociationAgarwal, Prachi P MD*; Seely, Jean M MD*; Perkins, D Garth MD†; Matzinger, Fred R MD*; Alikhan, Qasim MD‡Author Information From the *Department of Diagnostic Imaging, The Ottawa Hospital, Ottawa, Ontario, Canada; †Department of Laboratory Medicine, Division of Anatomical Pathology, The Ottawa Hospital, Ottawa, Ontario, Canada; and ‡Division of Rehabilitation Medicine (Pulmonary), The Ottawa Hospital, Ottawa, Ontario, Canada. Reprints: Jean M. Seely, MD, The Ottawa Hospital, Civic Campus, 1053 Carling Ave., Ottawa, Ontario, Canada K1Y 4E9 (e-mail: [email protected]). Journal of Thoracic Imaging: August 2005 - Volume 20 - Issue 3 - p 242-244 doi: 10.1097/01.rti.0000160733.74997.2d Buy Metrics Abstract We present the high resolution CT features of marked pulmonary fibrosis in a patient known to have pulmonary alveolar proteinosis (PAP) confirmed on open lung biopsy. Significant fibrosis in PAP is an extremely rare occurrence with only a few case reports. Our case demonstrated a predominantly central distribution, which has not been described previously. © 2005 Lippincott Williams & Wilkins, Inc.