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Diffuse Pulmonary Ossification

Kanne, Jeffrey P MD*; Godwin, J David MD*; Takasugi, Julie E MD; Schmidt, Rodney A MD, PHD; Stern, Eric J MD§

Journal of Thoracic Imaging: April 2004 - Volume 19 - Issue 2 - p 98-102
Review Article
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Diffuse pulmonary ossification (DPO) is an uncommon condition that is characterized by metaplastic bone formation in the lung parenchyma. It is usually not diagnosed clinically and may be apparent radiographically only when extensive. However, it is occasionally encountered at autopsy or on pathologic evaluation of surgical specimens. This article will review the clinical, histologic, and radiographic manifestations of DPO, focusing primarily on the chest radiograph and CT findings, both of which may be underappreciated, for even experienced radiologists may confuse DPO with other entities such as metastatic calcification as seen in chronic renal failure or chronic granulomatous disease.

From the *Department of Radiology, University of Washington School of Medicine, Seattle WA; †Department of Radiology, Veterans Administration Medical Center, Seattle WA; ‡Department of Pathology, University of Washington School of Medicine, Seattle WA; and §Department of Radiology, Harborview Medical Center, University of Washington School of Medicine, Seattle, WA.

Reprints: Jeffrey P. Kanne, MD, Department of Radiology, University of Washington School of Medicine, Box 357115, Seattle WA 98195-7115 (e-mail: jkanne@u.washington.edu).

© 2004 Lippincott Williams & Wilkins, Inc.