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Pulmonary Hamartoma: Unusual Radiologic Appearance

Shinkai, Masaharu MD*; Kobayashi, Hideo MD*; Kanoh, Soichiro MD*; Ozeki, Yuichi MD; Aida, Shinsuke MD; Motoyoshi, Kazuo MD*

Case Reports

A pulmonary nodule was incidentally detected in a 50-year-old man during a routine health evaluation. High-resolution computed tomography (HRCT) showed that the lesion had the appearance of a collection of multiple tiny nodules. Histologic examination of the resected specimen revealed a single hamartoma resembling a bunch of grapes. Pulmonary alveoli and bronchioles were entrapped within the hamartoma with tumor buds appearing in a multicentric manner, thereby producing the unusual HRCT findings. Review of chest radiographs taken over the previous 20 years indicated that the tumor doubling time was 4968 days.

From the *Third Department of Internal Medicine, the †Second Department of Surgery, and the ‡Department of Clinical Pathology, National Defense Medical College, Tokorozawa-city, Saitama, Japan.

Reprints: Hideo Kobayashi, MD, PhD, Third Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa-city, Saitama 359-8513, Japan (e-mail:

© 2004 Lippincott Williams & Wilkins, Inc.