Original ArticleTrousseau Syndrome Due to Pleural MesotheliomaMatsui, Hideaki MD; Nishinaka, Kazuto MD; Oda, Masaya MD; Kubori, Tamotsu MD, PhD; Udaka, Fukashi MD, PhDAuthor Information From the Department of Neurology, Sumitomo Hospital, Osaka, Japan. Reprints: H. Matsui, Department of Neurology, Sumitomo Hospital, 5-3-20 Nakanoshima, Kita-ku, Osaka, 530-0005, Japan. E-mail: [email protected]. The Neurologist: July 2007 - Volume 13 - Issue 4 - p 205-208 doi: 10.1097/01.nrl.0000253113.53846.ec Buy Metrics Abstract Background: Thrombosis involving a brain infarction frequently occurs in patients with a malignant tumor. Although nearly all types of tumor have been reported in association with a hypercoagulable state, pleural mesothelioma-associated Trousseau syndrome is extremely rare. Summary: A 69-year-old female was admitted to our hospital with cough, sputum, and breathing difficulties. She was diagnosed as having a mesothelioma from a percutaneous pleural biopsy. Although there were no risk factors for atherosclerosis, brain infarctions showed frequent relapses, even under anticoagulant therapy, and there was a marked hypercoagulable state. Conclusion: Attention should be paid to this syndrome when unexplained brain infarctions occur in patients with pleural mesothelioma. © 2007 Lippincott Williams & Wilkins, Inc.