Case Report/Case SeriesReversible Cerebral Vasoconstriction Syndrome in the Setting of COVID-19 and Pleomorphic Sarcoma A Case ReportHarahsheh, Ehab MBBS*; Gritsch, David MD*; Mbonde, Amir MBChB*; Apolinario, Michael MD†; Hoxworth, Joseph M. MD‡; Demaerschalk, Bart M. MD, MSc, FRCP(C)* Author Information Departments of *Neurology †Internal medicine ‡Radiology, Mayo Clinic College of Medicine and Science, Scottsdale, AZ E.H.: Mayo Clinic Arizona, Author, Design and conceptualized study; literature review; drafted the manuscript for intellectual content. D.G.: Mayo Clinic Arizona, Author, Literature review; revised the manuscript for intellectual content. A.M.: Mayo Clinic Arizona, Author, Revised the manuscript for intellectual content; Conceptualized and drafted figures. M.A.: Mayo Clinic Arizona, Author, Literature review; revised the manuscript for intellectual content; drafted the figures. J.M.H.: Mayo Clinic Arizona, Author, Conceptualized and drafted the figures. B.M.D.: Mayo Clinic Arizona, Author, Design and conceptualized study; revised the manuscript for intellectual content. The authors declare no conflict of interest. Correspondence to: Ehab Harahsheh, MBBS, Department of Neurology, Mayo Clinic in Arizona 13400 East Shea Boulevard, Scottsdale, AZ 85259. E-mail: [email protected]. The Neurologist: May 2022 - Volume 27 - Issue 3 - p 135-138 doi: 10.1097/NRL.0000000000000387 Buy Metrics Abstract Introduction: Reversible cerebral vasonstriction syndrome (RCVS) is an increasingly recognized clinical and radiologic syndrome. However, it has been rarely reported in the setting of the novel coronavirus disease-2019 (COVID-19) infection or sarcomatous tumors. RCVS might be the initial manifestations of COVID-19 infection or noncatecholamine producing masses including sarcoma. Case Report: A 44-year-old male who developed COVID-19–related symptoms followed by rapid onset of severe headaches in the setting of persistently elevated blood pressure (BP). Brain imaging showed multifocal arterial narrowing in the anterior and posterior circulation consistent with RCVS. Serial imaging demonstrated resolution of the arterial narrowing after BP control was achieved with improvement in the patient’s headaches. Further investigation for secondary causes of the patient’s elevated BP revealed a right renal mass, and the patient underwent right nephrectomy, and the biopsy results confirmed the diagnosis of pleomorphic sarcoma. Conclusion: Our case suggests a possible association between severe acute respiratory syndrome coronavirus 2 with development of RCVS, but further studies are needed to validate this observation, establish a causal relationship and define a pathophysiological mechanism. Considering tumors other than catecholamine-producing masses as a potential risk factor for developing RCVS might lead to earlier detection and treatment of any underlying malignancy in patients whom the main and sole presentation could be RCVS. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.