Case Report/Case SeriesCytomegalovirus-Associated Mild Encephalopathy/Encephalitis With Reversible Splenial LesionFu, Mao-Lin MD*; Han, Ning MD†; Wang, Wei MD†,‡Author Information *Department of Neurology, The 910th Hospital of the Joint Logistics Support Force of the Chinese PLA, Quanzhou, Fujian †Department of Neurology, Hebei General Hospital ‡Department of Graduate School, Hebei Medical University, Shijiazhuang, Hebei, China The study was approved by the Regional Committee for Ethics in Medical Research. The authors certify that they have obtained the appropriate patient consent form(s). In the form, the patient has given his consent for his images and other clinical information to be reported in the journal. The patient understands that his name and initial will not be published and due efforts will be made to conceal his identity, but anonymity cannot be guaranteed. The authors declare no conflict of interest. Correspondence to: Wei Wang, MD, Department of Neurology, Hebei General Hospital; Department of Graduate School, Hebei Medical University, Shijiazhuang, Hebei 050000, China. E-mail: [email protected]. The Neurologist: September 2021 - Volume 26 - Issue 5 - p 172-174 doi: 10.1097/NRL.0000000000000334 Buy Metrics Abstract Introduction: Mild encephalopathy with a reversible splenial lesion (MERS) is a clinical-radiologic syndrome presenting with a reversible lesion in the splenium of the corpus callosum. MERS is associated with many potential etiologies, including cytomegalovirus (CMV) infection in children. We report an adult patient with CMV-associated MERS. Case Report: A previously healthy 25-year-old man was admitted with a 4-day history of fever, headache, and vomiting. Brain magnetic resonance imaging demonstrated an isolated lesion of the splenium of the corpus callosum with hyperintensity on T2 and diffusion-weighted sequences and reduced values on apparent diffusion coefficient maps. High throughput gene detection for pathogens in cerebrospinal fluid revealed infection with CMV. The splenial lesion resolved 4 weeks after onset. Conclusion: This is the first report an adult patient with CMV-associated MERS. Recognition of this clinical-radiologic syndrome can guide diagnosis and management. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.