Case Report/Case SeriesDupuytren, Ledderhose, and Peyronie Diseases After Primidone Use For Essential TremorVasconcellos, Luiz Felipe R. MD, PhD; Nassif, Daniel MSc, MD; Spitz, Mariana MD, PhD Author Information Department of Neurology, Federal Hospital of Servidores do Estado, Rio de Janeiro-RJ, Brazil The authors declare no conflict of interest. Correspondence to: Luiz Felipe R. Vasconcellos, MD, PhD, Sacadura Cabral Street, 178. Saúde, Rio de Janeiro-RJ, 20221-903 Brazil. E-mail: [email protected]. The Neurologist: September 2019 - Volume 24 - Issue 5 - p 150-151 doi: 10.1097/NRL.0000000000000240 Buy Metrics Abstract Introduction: Dupuytren, Ledderhose, and Peyronie diseases are chronic fibrotic conditions related to progressive fibrosis of the palmar fascia, plantar fascia, and tunica albuginea, respectively. These conditions have been associated with antiepileptic drug use, mainly phenobarbital and primidone. Case Report: A 71-year-old man developed simultaneous Dupuytren, Ledderhose, and Peyronie diseases after primidone use for essential tremor. Conclusions: There are a few reports associating barbiturate use to connective tissue disorders, and some suggest that drug withdrawal may result in a better prognosis. Therefore, physicians must be aware of such adverse events when caring for patients on long-term barbiturate use. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.