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Cause or Consequence

The Relationship Between Cerebral Venous Thrombosis and Idiopathic Intracranial Hypertension

Türay, Sevim MD*; Kabakuş, Nimet MD*; Hanci, Fatma MD*; Tunçlar, Aslihan MD; Hizal, Mustafa MD

doi: 10.1097/NRL.0000000000000242
Original Article

Aim: The aims of our study were to refer to the complex relationship between idiopathic intracranial hypertension (IIHT) and cerebral sinovenous thrombosis (CSVT), and to determine the differences and commonalities between the patients with and without CSVT in their etiology, along with documenting the uncertainties in concluding on the diagnosis and treatment of these patients.

Material and Methods: IIHT was diagnosed according to Dandy criteria, while CSVT was screened for by way of a cranial magnetic resonance imaging for all patients and cranial magnetic resonance venography only if the magnetic resonance imaging was nebulous or there was a family history.

Results: We retrospectively evaluated a total of 26 patients (9 of whom had CSVT) diagnosed with IIHT between 2014 and 2018. A total of 9 patients with concurrent CSVT were described as suffering from vascular IIHT, while the remaining 17 were described as suffering from other IIHT. Demographic characteristics were similar in both groups (mean age: 12 vs. 11; male/female ratio: 2/7 vs. 5/12 in vascular IIHT and other IIHT, respectively). Clinical findings, cerebrospinal fluid-opening pressure values, and pathologies of etiology were also similar (vitamin D deficiency: 66% vs. 52%; vitamin B12 deficiency: 11% vs. none; iron deficiency: 22% vs. 11%; obesity: 22% vs. 23%). A mixture of acetazolamide, topiramate, anticoagulant therapy, and acetylsalicylic acid were given according to the diagnoses.

Conclusion: CSVT is a common clinical entity among the causes of IIHT, and it should be taken into consideration in this patient group. However, there is a need for a common guideline for laboratory and imaging methods to understand the etiopathogenesis of childhood IIHT and determine the patients at risk.

Departments of *Pediatric Neurology


Radiology, Faculty of Medicine, Abant İzzet Baysal University, Bolu, Turkey

Supported by the Pediatrics Department, Bolu Abant İzzet Baysal University.

The authors declare no conflict of interest.

Correspondence to: Sevim Türay, MD, Tip Fakultesi, Pediatric Neurology, Abant Izzet Baysal Universitesi, Bolu 14280, Turkey. E-mail:

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