Case Reports/Case SeriesAutoimmune Polyendocrine Syndrome-3 in a Patient With Late-onset Multiple SclerosisYokote, Hiroaki MD, PhD*; Nagasawa, Miki MD†; Ichijo, Masahiko MD*; Amino, Takeshi MD, PhD*; Fujigasaki, Hiroto MD, PhD*Author Information Departments of *Neurology †Endocrinology, Musashino Red Cross Hospital, Kyonan-cho, Musashino, Tokyo, Japan The authors declare no conflict of interest. Reprints: Hiroto Fujigasaki, MD, PhD, Department of Neurology, Musashino Red Cross Hospital, 1-26-1, Kyonan-cho, Musashino, Tokyo 180-8610, Japan. E-mail: [email protected]. The Neurologist: March 2012 - Volume 18 - Issue 2 - p 83-84 doi: 10.1097/NRL.0b013e318248ea2a Buy Metrics Abstract We present here the rare case of a 73-year-old patient with very late-onset multiple sclerosis who developed autoimmune polyendocrine syndrome (APS)-3. Despite only a few reports describing the association between multiple sclerosis and APS, both of these diseases have been shown to be associated with HLA-DR4. Intriguingly, the HLA genotype profile of this patient included HLA-DR4 which, fine mapped to the DRB1*0405-DQA1*0303-DQB1*0401 extended haplotype, reported to be a susceptibility haplotype for APS-3 in Japan. This unique genetic background might explain the clinical picture of this patient. © 2012 Lippincott Williams & Wilkins, Inc.