Case Report/Case SeriesIsolated Orbito-cerebral MucormycosisLau, Chi-Ieong MD*; Wang, Han-Cheng MD*,†; Yeh, Hsu-Ling MD*; Li, Chen-Hsien MD*Author Information *Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital †College of Medicine, National Taiwan University and College of Medicine, Taipei Medical University, Taipei, Taiwan Reprints: Han-Cheng Wang, MD, Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, 95 Wen-Chang Road, Shih-Lin District, Taipei, Taiwan. e-mail: email@example.com. The Neurologist: May 2011 - Volume 17 - Issue 3 - p 151-153 doi: 10.1097/NRL.0b013e3182173395 Buy Metrics Abstract Rhino-orbito-cerebral mucormycosis is a fatal infection in immunocompromised hosts. Prompt recognition of this clinical condition is essential for early diagnosis to avoid a delay of treatment. The presence of black eschar, usually in the nasal cavity, is the most alerting sign to the diagnosis. We present a patient with extremely fulminant ROCM in which the disease might be acquired via an orbital infection without nasal or paranasal involvement. With black eschars appearing at the bilateral canthi as the first alarm to extensive vascular involvement, the lethal infection rapidly evolved to occlusion of the bilateral ophthalmic arteries and eventually major intracranial arteries. © 2011 Lippincott Williams & Wilkins, Inc.