Case Report/Case SeriesEfficacy of Nebivolol and Amitriptyline in the Prophylaxis of Cyclic Vomiting Syndrome A Case ReportErturk, Ozdem MD; Uluduz, Derya MD; Karaali-Savrun, Feray MD Author Information From the Department of Neurology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey. Reprints: Ozdem Erturk, MD, Department of Neurology, Istanbul University Cerrahpasa Medical Faculty, 34098 Fatih, Istanbul, Turkey. E-mail: [email protected]. The Neurologist: September 2010 - Volume 16 - Issue 5 - p 313-314 doi: 10.1097/NRL.0b013e3181b120a6 Buy Metrics Abstract Background: Cyclic vomiting syndrome (CVS) is an episodic disorder with recurrent attacks of nausea and vomiting. The exact cause of the disorder is still unclear. It was first described in children but may affect patients of any age. The syndrome is frequently misdiagnosed, and patients receive redundant investigations and treatments. Patients are referred finally to a neurologist because of the differential diagnosis of abdominal migraine or abdominal epilepsy. Case Report: We present a 18-year-old girl with episodic nausea and vomiting attacks who was diagnosed as CVS. The attacks regressed with combination treatment with amitriptyline and nebivolol. Conclusion: CVS has no specific diagnostic test and the diagnosis is based on history, clinical presentation and exclusion of other possible causes with similar presentation. The syndrome has a strong association with migraine; treatment options may also overlap. Treatment is still based on case series and reports. Here, we aim to present the clinical features as well as treatment response of a patient with CVS. © 2010 Lippincott Williams & Wilkins, Inc.