Review ArticleAsymmetric Cortical Degenerative Syndromes An Integrated Approach to Clinical and Imaging Reviewda Rocha, Antônio José MD*; Braga, Flávio Túlio MD*; da Silva, Carlos Jorge MD*; Toyama, Carlos MD*; Gama, Hugo Pereira Pinto MD*; de Oliveira, Marco Antonio Conde MD† Author Information From the *Section of Neuroradiology, Centro de Medicina Diagnóstica Fleury and Santa Casa de Misericórdia de São Paulo; and †Section of Nuclear Medicine, Centro de Medicina Diagnóstica Fleury, São Paulo, SP, Brazil. The authors declare no conflict of interest. Reprints: Hugo Pereira Pinto Gama, MD, Fleury Medicina Diagnóstica, Neurorradiologia, Rua Cincinato Braga 282, Paraíso, São Paulo, SP, Brazil, CEP: 01333-910. E-mail: [email protected]. The Neurologist: September 2010 - Volume 16 - Issue 5 - p 298-305 doi: 10.1097/NRL.0b013e3181dba5bb Buy Metrics Abstract Background: The term asymmetric cortical degenerative syndromes (ACDSs) refers to any brain afflictions that result in selective atrophy, particularly with an asymmetric pattern. Regardless of the etiology, the resulting compromised profile reflects the affected topography, which correlates with the clinical findings, more than any specific neuropathologic entity. Review Summary: ACDS can represent a diagnostic challenge, because of an overlap of clinical manifestations, especially in the early stages. Magnetic resonance techniques are useful to understand nuclear medicine studies and to confirm areas of focal atrophy by providing anatomic details and allowing an accurate correlation with several different clinical settings. Conclusions: This article demonstrates a practical neuroradiologic approach for ACDS, including optimized imaging analysis (magnetic resonance and nuclear medicine studies), which correlates their patterns with clinical and pathologic findings of the most relevant disorders. © 2010 Lippincott Williams & Wilkins, Inc.