Case ReportPrimary Diffuse Meningeal MelanomatosisZadro, Ivana MD*; Brinar, Vesna V. MD, PhD*; Barun, Barbara MD*; Ozretić, David MD†; Pažanin, Leo MD‡; Grahovac, Gordan MD§; Habek, Mario MD*Author Information From the *Referral Center for Demyelinating Diseases of the Central Nervous System, University Department of Neurology, Zagreb School of Medicine and University Hospital Center, Zagreb, Croatia; Departments of †Radiology, and ‡Neuropathology, Zagreb School of Medicine and University Hospital Center, Zagreb, Croatia; and §Department of Neurosurgery, University Hospital Dubrava, Zagreb, Croatia. There is no conflict of interest. Reprints: Mario Habek, MD, University Department of Neurology, Zagreb School of Medicine and University Hospital Center, Kišpatićeva 12, HR-10000 Zagreb, Croatia. E-mail: firstname.lastname@example.org. The Neurologist: March 2010 - Volume 16 - Issue 2 - p 117-119 doi: 10.1097/NRL.0b013e3181c29ef8 Buy Metrics Abstract Primary diffuse meningeal melanomatosis can clinically mimic a wide variety of other conditions, including lymphoma, leukemia, neurosarcoidosis, metastatic carcinoma, acute disseminated encephalomyelitis, subacute meningitis, viral encephalitis, and idiopathic hypertrophic cranial pachymeningitis. We report on a young patient with primary diffuse meningeal melanomatosis who presented with papilledema, flaccid paraparesis, and cognitive impairment. The importance of imaging of the whole central nervous system, cerebrospinal fluid analysis, and pathohistological examination is emphasized in making the appropriate diagnosis. © 2010 Lippincott Williams & Wilkins, Inc.