Original ArticleSingle-Voxel Magnetic Resonance Spectroscopy of Brain Tissue Adjacent to Arachnoid Cysts of Epileptic PatientsOzisik, Handan Isin*; Sarac, Kaya†; Ozcan, Cemal‡ Author Information From the *Department of Neurology, Medical Faculty of Onsekiz Mart University, Çanakkale; Departments of †Radiology and ‡Neurology, Medical Faculty of İnönü University, Malatya, Turkey. Reprints: Handan Isin Ozisik, Department of Neurology, Çanakkale Onsekiz Mart Üniversitesi Tıp Fakültesi, Çanakkale Onsekiz Mart Üniversitesi Tıp Fakültesi, Nöroloji Anabilim Dalı, 17100 Çanakkale. E-mail: [email protected] or [email protected]. The Neurologist: November 2008 - Volume 14 - Issue 6 - p 382-389 doi: 10.1097/NRL.0b013e318177819c Buy Metrics Abstract Intracranial arachnoid cysts (ACs) are usually asymptomatic, benign developmental anomalies. The most frequent clinical manifestations are cranial expansion, hydrocephaly, headache, epileptic seizures, psychomotor retardation, and aphasia. It is unknown whether there is a correlation between intracranial AC and epileptic seizures without obvious intracranial pressure signs. In vivo magnetic resonance spectroscopy is a technique used for the noninvasive investigation of the various metabolites of cerebral biochemical reactions. Magnetic resonance spectroscopy is also being used increasingly commonly in epileptogenic situations as a noninvasive technique. The purpose of this study was to evaluate the proton magnetic resonance spectroscopic pattern of the contents of tissue adjacent to AC and to determine whether there are any characteristic spectral patterns that may be helpful in evaluating whether these lesions are epileptogenic foci. In conclusion, although the number of cases was limited, this finding may be seen as indicating that there is no association between AC and epilepsy. © 2008 Lippincott Williams & Wilkins, Inc.