Original ArticleHerpes Simplex Encephalitis Is Anticoagulation Safe?Jabbour, Pascal M. MD*; Ojemann, Steven G. MD† Author Information From the *Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania; and the †Department of Neurosurgery, University of Colorado Health Sciences Center, Denver, Colorado. Reprints: Pascal M. Jabbour, MD, 3903 City Avenue, Apartment C 1108, Philadelphia, PA 19131. E-mail: [email protected]. The Neurologist: May 2005 - Volume 11 - Issue 3 - p 187-189 doi: 10.1097/01.nrl.0000159761.57148.70 Buy Metrics Abstract Background: Herpes simplex encephalitis (HSE) still carries a high morbidity and mortality. Review Summary: The authors report a 27-year-old patient who presented with an HSE manifested by a high temperature, seizures, and headaches. His hospitalization course was complicated by a pulmonary embolism. After anticoagulation was started, the patient developed a right temporal hematoma at the same region of the abnormal signal on magnetic resonance imaging. The patient underwent a craniotomy and evacuation of the hematoma with an uneventful postoperative outcome. Conclusion: The safety of anticoagulation in HSE has not been raised in the literature previously, and it needs further study. © 2005 Lippincott Williams & Wilkins, Inc.