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Serum Leptin Level in Hypertensive Middle-Aged Obese Women

de Moraes, Camila*; Romero, Carla E. M.*; Farias-Silva, Elisāngela PhD†; Zanesco, Angelina PhD*

Preliminary Study

The mechanism by which adiposity can raise blood pressure is not fully understood. Leptin has been suggested as a possible cause of the arterial hypertension in obese subjects because leptin induces an increase in sympathetic activity. The aim of the present study is to evaluate serum leptin level, blood pressure, lipid profile, blood glucose, and insulin in obese women. Leptin, total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides were measured. Serum leptin was markedly higher in hypertensive obese women (92.3 ± 22 ng/mL, n = 7) as compared with normotensive obese women (37.7 ± 11 ng/mL, n = 7). Similarly, total cholesterol and LDL cholesterol were significantly elevated in the hypertensive group. No changes were observed in triglycerides and high-density lipoprotein cholesterol concentration between the 2 groups. There were no significant differences in plasma insulin concentration or blood glucose in both groups. In conclusion, our findings suggest a link among dyslipidemia, leptin level, and hypertension that might be relevant to the development of cardiovascular disease in obese subjects.

From the *Department of Physical Education, Bioscience Institute, UNESP, Rio Claro, Brazil; and the †Department of Physiology and Biophisic, Biology Institute, UNICAMP, Campinas, Brazil.

Reprints: Angelina Zanesco, PhD, Rua Guerino Bristotti, 794, Jardim Miriam, Campinas (SP), Brazil. E-mail:

© 2005 Lippincott Williams & Wilkins, Inc.