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00019616-200010060-00005ReviewThe EndocrinologistThe Endocrinologist© 2000 Lippincott Williams & Wilkins, Inc.10November 2000 p 389-396Type 2 Diabetes Mellitus in Children and AdolescenceA PrimerCME Review Articles: PDF OnlyJones, Kenneth L. M.D.*; Haghi, Marjan M.D.†UCSD School of Medicine, La Jolla, California 92093-0831.Address correspondence to: Kenneth Lee Jones, M.D., Professor of Pediatrics, UCSD School of Medicine, La Jolla, CA 92093-0831. Phone: 619-543-6933; Fax: 619-543-5512; E-mail:[email protected]*The author discloses: Consultant for Bristol-Meyers Squibb, Takeda, and SmithKline Beecham.†No conflict of interest to disclose.This article contains discussion of unlabeled/investigational uses of pharmaceuticals and/or medical devices.AbstractType 2 diabetes mellitus traditionally has been considered a disorder of adults, rarely encountered in children. During the past 10 years, the disorder has been described with increasing frequency in the young, especially in adolescents. This increase has been so striking that it has been described as an epidemic. Although most races and ethnic origins have been affected, those adolescents affected are primarily Native American or North American aboriginal or have Mexican, African, or Asian genetic heritages. This review is intended to serve as a primer for those unfamiliar with this disease as it occurs in children. It briefly discusses the forms of diabetes currently being found in children and specifically reviews the clinical reports of type 2 diabetes, describing its epidemiology, clinical manifestations, diagnosis, and differential diagnosis. Approaches to therapy are discussed with attention to particular problems in this young population. Current recommendations for therapy are outlined and the recent report of a controlled trial of metformin in children is discussed, as is the authors' experience. The need to begin careful studies in children of glycemic management with oral antidiabetic drugs and to begin study of therapy of comorbid conditions is also addressed.The Endocrinologist 2000; 10: 389-396Section DescriptionCHIEF EDITOR'S NOTE: This article is the 33rd of 36 that will be published in 2000 for which a total of up to 36 Category 1 CME credits can be earned. Instructions for how credits can be earned appear following the Table of Contents.Type 2 Diabetes Mellitus in Children and Adolescence: A PrimerJones Kenneth L. M.D.; Haghi, Marjan M.D.CME Review Articles: PDF OnlyCME Review Articles: PDF Only610p 389-396