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00019616-200010060-00006ReviewThe EndocrinologistThe Endocrinologist© 2000 Lippincott Williams & Wilkins, Inc.10November 2000 p 397-402Review of Precocious Puberty Part IIGonadotropin-Independent Precocious PubertyCME Review Articles: PDF OnlyTang, May*; Fenton, Cydney M.D.*; Poth, Merrily M.D.*Howard University School of Medicine (M.T.), Washington, DC; Department of Pediatrics (C.F., M.P.), F. Edward Hebert School of Medicine, Uniformed Services University of Health Sciences, Bethesda, Maryland; and Walter Reed Army Medical Center (C.F., M.P.), Washington, DC.Address correspondence to: M. Poth, M.D., Professor, Department of Pediatrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814. Phone: 301-295-0220; Fax: 301-295-6441; E-mail: [email protected] opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the opinions of the Uniformed Services University of the Health Sciences, the Department of the Army, or the Department of Defense.*No conflict of interest to disclose.AbstractThe majority of cases of early pubertal maturation are due to premature activation of the hypothalamic-pituitary-gonadal axis. However, it is important to identify the small subset of individuals in whom the process is independent of gonadotropin secretion because the causes of the disorder, treatment options, and long-term implications are very different in this group of patients. After ruling out a gonadal or adrenal neoplasm and exogenous hormone exposure as causative, diagnostic possibilities include McCune Albright syndrome and familial male precocious puberty, so-called “testotoxicosis”. As the process is independent of GnRH secretion, the use of GnRH analogues is not effective. All therapeutic approaches for these disorders involve the use of drugs that inhibit sex steroid synthesis and/or action. In some cases reassurance and monitoring may be sufficient or even preferable because none of the currently available or recommended treatment paradigms is without potential complications.The Endocrinologist 2000; 10: 397-402Section DescriptionCHIEF EDITOR'S NOTE: This article is the 34th of 36 that will be published in 2000 for which a total of up to 36 Category 1 CME credits can be earned. Instructions for how credits can be earned appear following the Table of Contents.Review of Precocious Puberty Part II: Gonadotropin-Independent Precocious PubertyTang May; Fenton, Cydney M.D.; Poth, Merrily M.D.CME Review Articles: PDF OnlyCME Review Articles: PDF Only610p 397-402