Editorial: PDF OnlyAdenocarcinoma of the Male Breast after Spironolactone-Induced Gynecomastia Case ReportWilson, Rodman M.D.; Lanier, James M.D. Author Information Departments of Medicine (R.W.) and Pathology (J.L.), Providence Hospital, Anchorage, AK99501 The Endocrinologist 6(2):p 86-88, March 1996. Buy Abstract A man was given spironolactone and other drugs intermittently for control of hypertension. He developed gynecomastia bilaterally; spironolactone was stopped. Three years later, fatal infiltrating ductal adenocarcinoma of the breast supervened. This sequence of events raises suspicion that spironolactone therapy led to lethal breast carcinoma. © Lippincott-Raven Publishers.