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Overt Hyperthyroidism Secondary to Metastatic Gestational Trophoblastic Neoplasm

Toscano-Zukor, Amy M. DO*; Wang, Xiangbing MD, PhD, FACE†

doi: 10.1097/TEN.0b013e3180ca75ed
CME Review Article #19

Gestational trophoblastic disease is a rare cause of overt hyperthyroidism. Biochemical and clinical hyperthyroidism results from elevated levels of human chorionic gonadotropin, a hormone that is structurally similar to thyroid stimulating hormone. We report a case of a woman with gestational trophoblastic neoplasm with pulmonary metastases who presented with signs, symptoms, and biochemical evidence of hyperthyroidism. The hyperthyroidism improved dramatically with β-blocker therapy and combination chemotherapy.

*Endocrinology Fellow and †Assistant Professor of Medicine, Department of Medicine, Division of Endocrinology University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, New Brunswick, New Jersey.

The authors have disclosed that they have no significant relationships with or financial interests in any commercial company that pertains to this educational activity.

Lippincott Continuing Medical Education Institute, Inc. has identified and resolved all faculty conflicts of interest regarding this educational activity.

Reprints: Amy M. Toscano-Zukor, DO, UMDNJ-RWJMS Division of Endocrinology, MEB 384B, PO Box 19, 1 RWJ Place, New Brunswick, NJ 08903-0019.

Chief Editor's Note: This article is the 19th of 36 that will be published in 2007 for which a total of up to 36 AMA PRA Category 1 Credits™ can be earned. Instructions for how credits can be earned precede the CME Examination at the back of this issue.

© 2007 Lippincott Williams & Wilkins, Inc.