Secondary Logo

Institutional members access full text with Ovid®

Tumor-induced Osteomalacia Localization by Whole-body Sestamibi Scan

Ing, Steven W. MD, MSCE*; Iwenofu, O. Hans MD, FCAP†; Mayerson, Joel L. MD‡; Hall, Nathan C. MD, PhD§

doi: 10.1097/TEN.0b013e3181fc2d41
Case Report

Tumor-induced osteomalacia is a paraneoplastic syndrome caused by a mesenchymal tumor elaborating a hormone that induces renal-phosphate wasting. Clinical manifestations include hypophosphatemia, muscle weakness, bone pain, osteomalacia, and fractures. The debilitating disorder may be completely cured if the tumor is surgically removed, but its localization can be clinically challenging. In this case report, we discuss the clinical presentation, biochemical, radiologic, and microscopic data in a 58-year-old man with tumor-induced osteomalacia in whom tumor localization was successful via whole-body sestamibi scanning.

From the Departments of *Internal Medicine, †Pathology and Laboratory Medicine, ‡Orthopedic Surgery, and §Radiology, The Ohio State University Medical Center, Columbus, OH.

Reprints: Steven W. Ing, MD, MSCE, 491 McCampbell Hall, 1581 Dodd Drive, Columbus, OH 43210–1296. E-mail:

© 2010 Lippincott Williams & Wilkins, Inc.