Case–Control Study of Anaplastic Thyroid Cancer: Papillary Thyroid Cancer Patients as ControlsZivaljevic, Vladan MD, PhD*; Vlajinac, Hristina MD, PhD†; Marinkovic, Jelena MD, PhD‡; Sipetic, Sandra MD, PhD†; Paunovic, Ivan MD, PhD*; Diklic, Aleksandar MD, PhD*; Kalezic, Nevena MD, PhD*Author Information From the *Center for Endocrine Surgery, Institute of Endocrinology, Clinical Center of Serbia, Belgrade, Serbia; †Institute of Epidemiology, School of Medicine, Belgrade University, Belgrade, Serbia; and ‡Institute of Medical Statistics and Informatics, School of Medicine, Belgrade University, Belgrade, Serbia. Reprints: Vladan Zivaljevic, MD, PhD, Center for Endocrine Surgery, Institute of Endocrinology, Clinical Center of Serbia, Koste Todorovica 8, 11000 Belgrade, Serbia. E-mail: [email protected] or [email protected] The Endocrinologist: November/December 2010 - Volume 20 - Issue 6 - pp 308-311 doi: 10.1097/TEN.0b013e3181fd02f2 Buy Metrics Abstract The aim of the study was to examine the factors which play a role in the occurrence of differentiated thyroid cancer as related to anaplastic thyroid cancer (ATC). A case–control study was performed during the period 1993 to 2005. The case group comprised of 126 patients with ATC. The control group comprised of 126 patients with papillary thyroid cancer. Cases were individually matched by gender and place of residence. ATC was significantly related to older age (odds ratio = 1.11, 95% confidence interval = 1.07–1.14) and goiter (odds ratio = 1.20, 95% confidence interval = 1.07–1.35). © 2010 Lippincott Williams & Wilkins, Inc.