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Hyperandrogenism in Postmenopausal Women, Solved After “White” Oophorectomy

Guadalix, Sonsoles MD*; Vazquez, Tamara MD†; Jodar, Esteban MD, PhD*; Fernandez, Sofia MD‡

doi: 10.1097/TEN.0b013e3181c204d1
Case Report

Clinical signs of hyperandrogenism in postmenopausal women should be studied to determine the source of the androgens. A postmenopausal woman with clinical and biochemical hyperandrogenism is described. Laboratory tests pointed to the ovary as the source of androgen production but imaging showed no abnormalities in the ovaries or adrenal glands. Bilateral oophorectomy was performed. Histopathological study showed only atrophic ovaries. The hyperandrogenism, however, was resolved. Menopausal ovaries have endocrine activity and secrete androgens. This case illustrates that postmenopausal ovaries can produce hyperandrogenism even when no abnormality is found on histopathological study. Bilateral oophorectomy is recommended in cases of hyperandrogenism appearing at menopause when no adrenal abnormalities are present.

From the *Endocrinology Service, †Family doctor, and ‡Pathology Service, de Octubre University Hospital, Avda Córdoba s/n, Madrid, Spain.

Reprints: Sonsoles Guadalix, MD, 12 de Octubre University Hospital, Avda Córdoba s/n, 28041 Madrid, Spain. E-mail:

© 2009 Lippincott Williams & Wilkins, Inc.