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Diffusing Lung Capacity of Carbon Monoxide/Alveolar Volume as an Index for Evaluating Diffusing Capacity of the Acromegalic Lung

Saler, Tayyibe MD*; Ucak, Sema MD*; Yesim, Tijen MD*; Cakmak, Gulfidan MD†; Altuntas, Yuksel MD*

doi: 10.1097/TEN.0b013e3181c08648
Preliminary Study
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Background and Objectives: Acromegaly alters the structure, elasticity, and function of the entire respiratory apparatus. The purpose of the present study was to compare the diffusing capacity in patients with acromegaly and healthy subjects to elucidate the usefulness of diffusing lung capacity of carbon monoxide/alveolar volume (DLCO/VA) in the evaluation of respiratory functions of patients with acromegaly.

Patients and Methods: A total of 75 subjects attending Endocrinology and Metabolism Clinics at Sisli Etfal Training and Research Hospital between May 2007 and May 2008 were enrolled in the study.

Results: Acromegaly group included 44 patients (19 males, 25 females; mean age: 46.25 ± 2.1 years). Control group included 31 healthy subjects (9 males, 22 females; mean age: 40.92 ± 1.88). There was no statistical difference in gender distribution between patients and control groups (P > 0.05). Body mass indices were also similar between control and patient groups (P > 0.05). DLCO was similar in patients with acromegaly and healthy subjects (P > 0.05). However, the DLCO/VA was reduced significantly in patients with acromegaly when compared with control values (P < 0.01).

Conclusions: DLCO is similar in acromegalic and healthy subjects; DLCO/VA, however, may be a useful index for evaluating the respiratory dysfunction in acromegaly.

From the *Endocrinology and Metabolism Diseases Clinic, Sisli Etfal Training and Research Hospital, Sisli, Istanbul, Turkey; and †Division of Chest Diseases, Haseki Training and Research Hospital, Istanbul, Turkey.

Reprints: Tayyibe Saler, MD, Endocrinology and Metabolism Diseases Clinic, Sisli Etfal Training and Research Hospital, Sisli, Istanbul, Turkey. E-mail: taybe1970@hotmail.com.

© 2009 Lippincott Williams & Wilkins, Inc.