Subacute Thyroiditis Associated With Pseudomonas putida Bacteremia in a Patient With Diabetes and Bronchial Asthma: A Case ReportSu, Sheng-Chiang MD; Hung, Yi-Jen MD; Hsieh, Chang-Hsun MDAuthor Information From the Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China. Reprints: Chang-Hsun Hsieh, Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, 325, Section 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan, Republic of China. E-mail: [email protected] The Endocrinologist: September/October 2009 - Volume 19 - Issue 5 - pp 229-231 doi: 10.1097/TEN.0b013e3181b658af Buy Metrics Abstract Pseudomonas putida is thought to be nonpathogenic, and rarely causes true clinical infection. We present a patient with new-onset diabetes mellitus and bronchial asthma, who experienced P. putida bacteremia and, subsequently, subacute thyroiditis. This association has not been described previously. After administration of ceftazidime, the patient's condition improved but fever persisted and pain in the thyroid glands developed. Subacute thyroiditis was confirmed after a series of examinations. After treatment with nonsteroidal anti-inflammatory drugs and oral prednisolone, her condition improved, but subclinical hyperthyroidism developed after a 3-month period of therapy. There is increasing evidence that through molecular mimicry, P. putida can induce various autoimmune disorders; this may demonstrate the association of P. putida infection with subacute thyroiditis by an unknown mechanism. To our knowledge, our patient is the first case of subacute thyroiditis associated with P. putida bacteremia. © 2009 Lippincott Williams & Wilkins, Inc.