Preoperative Elevated Serum Growth Hormone is Preventive of Osteopenia in Postsurgical Patients With Pituitary Somatotroph Adenomas: Comparison With Clinically Nonfunctioning AdenomasSasaki, Mitsuyoshi MD, PhD*; Okazaki, Ryo MD, PhD†; Inoue, Daisuke MD, PhD†; Nakashima, Michi MD*; Ide, Fuyuaki MD*; Nakaguchi, Hiroshi MD, PhD*; Yamada, Shoko M. MD, PhD*; Hoya, Katsumi MD, PhD*; Murakami, Mineko MD, PhD*; Mizutani, Akiko PhD*; Okinaga, Hiroko MD, PhD‡; Matsuno, Akira MD, PhD*Author Information From the *Department of Neurosurgery, †Third Department of Medicine, Teikyo University Chiba Medical Center, Chiba, Japan; and ‡Department of Endocrinology, Teikyo University, Tokyo, Japan. Reprints: Akira Matsuno, MD, PhD, Department of Neurosurgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara City, Chiba 299-0111, Japan. E-mail: [email protected] The Endocrinologist: September/October 2009 - Volume 19 - Issue 5 - pp 208-210 doi: 10.1097/TEN.0b013e3181b66096 Buy Metrics Abstract To investigate the influence of preoperatively elevated growth hormone to bone mass in acromegalic patients, bone mineral density (BMD), and urinary type I collagen N-telopeptide were analyzed in postoperative patients with somatotroph adenomas (SA), in comparison with patients with clinically nonfunctioning adenomas (NF). The mean T and z scores of BMD in the radius of postoperative patients with SA were significantly higher than those of postoperative patients with NF. There was no significant difference in the mean T and z scores of BMD in the lumbar spine between postoperative patients with SA and those with NF. Thus, BMD in the radius is preferentially maintained in postoperative patients with SA. This result suggests that the preoperative elevation of growth hormone and insulin-like growth factor-1 are beneficial in the maintenance of bone mass in acromegalic patients. © 2009 Lippincott Williams & Wilkins, Inc.