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Novel Therapy: Insulin, Heparin, and Octreotide in the Treatment of Hypertriglyceridemia, Dramatic Results

Greenberg, Bruce August MD, MBA*; Hamam, Hisham Doowd MD†; Powers, Christopher Richard MD*; LeMar, Homer Jess MD‡; Oliver, Thomas G. MD‡

doi: 10.1097/TEN.0b013e318186f205
Case Report

Profound hypertriglyceridemia (HTG) is uncommon and often associated with acute pancreatitis. HTG may result from congenital disorders, metabolic diseases, and medications among other causes. The acute management of HTG is not clear, although the combination of insulin and heparin has shown efficacy. Octreotide, a somatostatin analog, has been mildly efficacious in pancreatitis. We present a case of profound HTG and pancreatitis-treated combination of insulin and heparin with octreotide and compare this to previous reports.

From the *Critical Care, Pulmonary, and Sleep Medicine Service, and ‡Endocrine Service, †Department of Medicine, William Beaumont Army Medical Center, El Paso, Texas.

The views expressed in this article are those of the authors and do not reflect the official policy of William Beaumont Army Medical Center, the Department of the Army, the Department of Defense, or the US Government.

Reprints: Thomas George Oliver, MD, Endocrine Service, Department of Medicine, William Beaumont Army Medical Center, 5005 North Piedras Street, El Paso, Texas. E-mail:

© 2008 Lippincott Williams & Wilkins, Inc.