A Case of Pseudohypoparathyroidism Type 1b Associated With a Bartter-like Syndrome : The Endocrinologist

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CME Review Article #3

A Case of Pseudohypoparathyroidism Type 1b Associated With a Bartter-like Syndrome

Suneja, Manish MD*; Dixon, Bradley S. MD†

Author Information

*Assistant Professor and †Associate Professor, Division of Nephrology, Department of Medicine, University of Iowa School of Medicine and University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Dr. Suneja has disclosed that he has a current relationship/financial interest with Baxter. Dr. Dixon has disclosed that he has past relationships/financial interests with the National Institutes of Health, the Department of Veterans Affairs, Proteon Therapeutics, and Pervasis Therapeutics and current relationships/financial interests with the National Institutes of Health, the Department of Veterans Affairs, and Proteon Therapeutics.

All staff in a position to control the content of this CME activity have disclosed that they have no financial relationships with, or financial interests in, any commercial companies pertaining to this educational activity.

Lippincott CME Institute has identified and resolved all faculty and staff conflicts of interest regarding this educational activity.

Reprints: Manish Suneja, MD, University of Iowa School of Medicine, 200 Hawkins Drive, W 348 GH, Iowa City, IA 52242-1081. E–mail: [email protected].

Chief Editor's Note:This article is the 3rd of 18 that will be published in 2008 for which a total of up to 18 AMA PRA Category 1 Credits™ can be earned. Instructions for how credits can be earned precede the CME Examination at the back of this issue.

The Endocrinologist 18(1):p 44-46, January 2008. | DOI: 10.1097/TEN.0b013e3181655544

Abstract

Background: 

Pseudohypoparathyroidism (PHP), a disorder characterized by end-organ resistance to parathyroid hormone is divided into types 1 a, b, and c and type 2. We describe a patient with the simultaneous presentation of PHP-1b and a Bartter-like syndrome.

Case Report: 

A young woman presenting with clinical and biochemical features of PHP-1b was found to have hypokalemic metabolic alkalosis and hypomagnesemia with renal potassium wasting, normal urinary calcium excretion, and elevated renin and aldosterone levels consistent with a Bartter-like syndrome.

Conclusion: 

This is the first case, to our knowledge, of a patient manifesting both PHP-1b and a Bartter-like syndrome. The coexistence of these 2 rare diseases in the same person could be a coincidence or it could suggest a new mutation that links the diseases.

© 2008 Lippincott Williams & Wilkins, Inc.

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