CME Review Article #26Obesity and Growth Disorders Festschrift Dedicated to George A. BurghenRose, Susan R. MD Author Information Professor of Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. The author has disclosed that she has no significant relationships with or financial interests in any commercial company that pertains to this educational activity. Lippincott Continuing Medical Education Institute, Inc. has identified and resolved all faculty conflicts of interest regarding this educational activity. Reprints: Susan R. Rose, MD, 3333 Burnet Ave., MLC 7012, Cincinnati, OH 45229. E-mail: [email protected]. Chief Editor's Note:This article is the 26th of 36 that will be published in 2007 for which a total of up to 36 AMA PRA Category 1 Credits™ can be earned. Instructions for how credits can be earned precede the CME Examination at the back of this issue. The Endocrinologist 17(5):p 267-272, September 2007. | DOI: 10.1097/TEN.0b013e318156bfe6 Buy CME Test Metrics Abstract This summary was presented at the Festschrift dedicated to George A. Burghen, MD, who has devoted his career at the University of Tennessee, Memphis, to improving care of children with disorders of glucose metabolism, including obesity and type 1 and type 2 diabetes mellitus. This article reviews the mechanisms associating growth disorders with obesity. Most commonly, obesity (overnutrition) leads to accelerated growth rate and tall stature during childhood with early achievement of normal adult height. Small stature associated with obesity during childhood and as an adult can result from a diverse set of conditions. These include being born small for gestational age, postnatal malnutrition, hormone abnormalities such as deficiencies of growth hormone or thyroid hormone, late effects after childhood cancer, certain medications, and genetic syndromes. Common features of growth disorders in the context of obesity include limited growth hormone or thyroid hormone or their action, or limited sensitivity to insulin action. Finally, abnormalities of leptin and newly identified appetite-regulating peptides also lead to poor growth and overweight. Obesity in the general population is much more likely to result from excess calories and sedentary lifestyle than from any of the conditions discussed above. © 2007 Lippincott Williams & Wilkins, Inc.