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Value of Low Levels of Anti-TPO Antibodies in Patients With Suspicion of Hashimoto Thyroiditis

Eising, Ernst G. PD Dr med; Jentzen, Walter Dr rer nat; Freudenberg, Lutz Dr med; Bockisch, Andreas Prof Dr med, Dr rer nat

doi: 10.1097/01.ten.0000261444.72452.5b
Preliminary Study

In clinical practice, many patients do not show the full symptoms of Hashimoto thyroiditis. The titer of the anti-TPO antibodies (ATAB) is often detectable but not pathologically elevated. This study evaluates the clinical status of patients with low ATAB titers.

Sixty-eight consecutive patients (55 female, 13 male; age: 24–84 years; mean: 55.4 years) with detectable titers of ATAB were investigated by clinical status, ultrasound, and thyroid scintigraphy with Tc-99m.

Eighteen patients had pathologically elevated titers of ATAB. Fifty-eight patients with detectable ATAB titers had clinical symptoms, 46 hypoechoic tissue by ultrasound, 17 a decrease in thyroid gland volume, and 14 a thyroid-stimulating hormone >2.5 mU/L.

Patients with low titers of ATAB and thyroid-stimulating hormone values in the upper reference interval (>2.5 mU/L) can have symptoms compatible with thyroid dysfunction and deserve a trial of therapy.

From the Clinic for Nuclear Medicine, University of Essen, Germany.

Reprints: Dr Ernst Eising, Elper Weg 66, D-45657 Recklinghausen, Germany. E-mail:

© 2007 Lippincott Williams & Wilkins, Inc.