Acromegaly Masquerading as Polycystic Ovary SyndromeRenner, Matthew MD*; Eyster, Kathleen PhD†; Hansen, Keith MD‡Author Information *Resident, Exempla-St. Joseph Hospital, Denver, Colorado; †Professor and PhD Researcher, Department of Basic Biomedical Sciences and Obstetrics and Gynecology, Vermillion, South Dakota; and ‡Professor and Chairman, Department of Obstetrics and Gynecology, Sanford School of Medicine of the University of South Dakota, Sioux Falls, South Dakota. The authors have disclosed that they have no significant relationships with or financial interests in any commercial company that pertains to this educational activity. Lippincott Continuing Medical Education Institute, Inc. has identified and resolved all faculty conflicts of interest regarding this educational activity. Reprints: Keith A. Hansen, MD, Department of Obstetrics and Gynecology, Sanford School of Medicine of the University of South Dakota, 1400 West 22nd Street, Sioux Falls, South Dakota 57105. E-mail: [email protected] Chief Editor's Note: This article is the 10th of 36 that will be published in 2007 for which a total of up to 36 AMA PRA Category 1 Credits™ can be earned. Instructions for how credits can be earned precede the CME Examination at the back of this issue. The Endocrinologist: March/April 2007 - Volume 17 - Issue 2 - pp 119-121 doi: 10.1097/01.ten.0000261477.47197.c2 Buy Take the CME Test Metrics Abstract This case describes a growth hormone–prolactin, cosecreting pituitary microadenoma that presented with chronic, hyperandrogenic anovulation. A 37-year-old parous patient presented with 1 year of irregular cycles unresponsive to clomiphene citrate and a mildly elevated prolactin. Laboratory evaluation demonstrated hyperprolactinemia with an elevated, age-adjusted, insulin-like growth factor-1 level, and nonsuppressed growth hormone following glucose loading. Magnetic resonance imaging revealed a pituitary microadenoma, which was removed by trans-sphenoidal microsurgery. The diagnosis of acromegaly is often delayed because of the insidious progression and frequently subtle, early manifestations of this disease. In females, the second most common presenting symptom for acromegaly is irregular menses. This case confirmed the value of careful evaluation of patients who present with symptoms suggestive of polycystic ovary syndrome, especially if there are unusual signs or symptoms. © 2007 Lippincott Williams & Wilkins, Inc.