Celiac disease is a disorder resulting from exposure of predisposed individuals to certain grain proteins and is associated with many autoimmune endocrine disorders. This condition may occur with classic symptoms of malabsorption or with minimal or no gastrointestinal symptoms. Patients may present with hypocalcemia, osteoporosis, or osteomalacia. Because of decreased intestinal absorption of levothyroxine, celiac disease may present with excessive levothyroxine requirements in hypothyroid patients. Furthermore, celiac disease is seen in increased frequency in patients with type 1 diabetes mellitus and should strongly be considered in the differential diagnosis of diarrhea or weight loss in patients with type 1 diabetes mellitus. This article describes the authors’ experience with celiac disease and emphasizes the ways it may present to clinical endocrinologists.