Journal Logo

You can read the full text of this article if you:

Access through Ovid
00019616-200010060-00004ReviewThe EndocrinologistThe Endocrinologist© 2000 Lippincott Williams & Wilkins, Inc.10November 2000 p 383-388Lipoprotein (a), Apolipoprotein (a) Phenotypes, and Thyroid Autoimmunity in Uremic PatientsCME Review Articles: PDF OnlyBairaktari, Eleni T. Ph.D.*; Milionis, Haralampos J. M.D.*; Katopodis, Kostas M.D.*; Tzallas, Christos Ph.D.*; Tselepis, Alexandros D. Ph.D.*; Tsolas, Orestes Ph.D.*; Siamopoulos, Kostas C. M.Sc., M.D., F.R.S.H.*; Elisaf, Moses S. M.D., F.R.S.H.*Department of Internal Medicine (H.J.M., K.K., A.D.T., K.S., M.S.E.) and Laboratory of Biochemistry of the University Hospital (E.T.B., C.T., O.T.), Medical School, University of Ioannina, Ioannina, Greece.Address correspondence to: Moses Elisaf, M.D., F.R.S.H., Associate Professor of Medicine, Department of Internal Medicine, Medical School, University of Ioannina, GR 451 10 Ioannina, Greece. Phone: 30-651-97509; Fax: 30-651-45944.*No conflict of interest to disclose.AbstractPatients with end-stage renal disease (ESRD) on hemodialysis (HD) or continuous ambulatory peritoneal dialysis (CAPD), as well as undialyzed patients with chronic renal failure (CRF) exhibit raised serum lipoprotein [Lp(a)] levels. It is also known that uremia is often associated with thyroid function disturbances. There is conflicting evidence about the association of thyroid autoimmunity and elevated Lp(a) levels in euthyroid males and postmenopausal females. Hence, it would be intriguing to demonstrate a pathophysiologic interrelation between thyroid autoimmunity and Lp(a) concentrations in patients with renal function impairment.We undertook the present study to examine the correlation of thyroid autoimmunity with Lp(a) levels and the corresponding apolipoprotein [Apo(a)] phenotypes in patients with ESRD on dialysis and in undialyzed patients with mild/moderate CRF. 80 patients undergoing maintenance HD, 22 patients undergoing CAPD, 56 undialyzed CRF patients (serum creatinine 1.8-8 mg/dL) and 115 normal subjects were studied.All patient-groups had increased serum Lp(a) concentrations compared to controls. Thyroid autoantibodies were present in a considerable proportion of uremic patients (23.75% HD, 40.9% CAPD, and 19.65% CRF patients). Patients with high molecular weight (HMW) Apo(a) isoforms had significant elevations in Lp(a) levels compared to controls, whereas these differences were minor with regard to low molecular weight (LMW) isoforms. There was no evidence of significant differences in serum Lp(a) concentrations between subjects with or without thyroid autoimmunity in all groups studied regardless of the stage of renal failure or the dialysis modality.The Endocrinologist 2000; 10: 383-388Section DescriptionCHIEF EDITOR'S NOTE: This article is the 32nd of 36 that will be published in 2000 for which a total of up to 36 Category 1 CME credits can be earned. Instructions for how credits can be earned appear following the Table of Contents.Lipoprotein (a), Apolipoprotein (a) Phenotypes, and Thyroid Autoimmunity in Uremic PatientsBairaktari Eleni T. Ph.D.; Milionis, Haralampos J. M.D.; Katopodis, Kostas M.D.; Tzallas, Christos Ph.D.; Tselepis, Alexandros D. Ph.D.; Tsolas, Orestes Ph.D.; Siamopoulos, Kostas C. M.Sc., M.D., F.R.S.H.; Elisaf, Moses S. M.D., F.R.S.H.CME Review Articles: PDF OnlyCME Review Articles: PDF Only610p 383-388