Familial Cushing's Syndrome with Idiopathic ACTH-Independent Bilateral Macronodular Adrenocortical Hyperplasia Successfully Treated by Laparoscopic Adrenalectomy* : The Endocrinologist

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00019616-200010050-00008ReportThe EndocrinologistThe Endocrinologist© 2000 Lippincott Williams & Wilkins, Inc.10September 2000 p 341-346Familial Cushing's Syndrome with Idiopathic ACTH-Independent Bilateral Macronodular Adrenocortical Hyperplasia Successfully Treated by Laparoscopic Adrenalectomy*Case Reports: PDF OnlyTollin, Steven R. M.D.; Resta, Christine M.D.; Cooper, Robert M.D.; Westra, William H. M.D.; Udelsman, Robert M.D.Department of Medicine (S.R.T., R.C.), Division of Endocrinology and Metabolism, Winthrop-University Hospital and The State University of New York at Stony Brook School of Medicine, Mineola, New York, 11501; Department of Medicine (C.R.), Division of Endocrinology and Metabolism, The New York Hospital-Medical Center of Queens and The Albert Einstein College of Medicine, Bronx, New York, 10467; and Department of Pathology (W.H.W.) and Department of Surgery (R.U.), Division of Oncologic and Endocrine Surgery, The Johns Hopkins Hospital and The Johns Hopkins School of Medicine, Baltimore, Maryland, 21205.Address correspondence to: Steven R. Tollin, M.D., Lincoln Green Apartments, 4000 Presidential Boulevard, Apt. 1510, Philadelphia, PA 19131. Phone: 215-879-4895; Fax. 717-290-3637; E-mail:[email protected]*These data were presented in part at the 80th Annual Meeting of The Endocrine Society, June 24-27, 1998, New Orleans, Louisiana.AbstractACTH-independent Cushing's syndrome secondary to ACTH-independent bilateral macronodular adrenocortical hyperplasia (AIBMAH) is an uncommon disorder, and in most cases the precise etiology has not been determined. We report a case of a 57-year-old woman who presented with signs and symptoms of Cushing's syndrome who was determined to have AIBMAH. The patient was successfully treated by bilateral laparoscopic adrenalectomy. Curiously, the patient's brother appeared to have the same disease. Although food-induced Cushing's syndrome was excluded, the mechanism leading to this patient's syndrome was not determined. This case, in addition to two other reported cases, shows that Cushing's syndrome associated with AIMBAH may occur on a familial basis. This case also shows that laparoscopic adrenalectomy may be used in lieu of the traditional surgical approach in these patients.▪The Endocrinologist 2000; 10: 341-346Familial Cushing's Syndrome with Idiopathic ACTH-Independent Bilateral Macronodular Adrenocortical Hyperplasia Successfully Treated by Laparoscopic Adrenalectomy<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">*</sup>Tollin Steven R. M.D.; Resta, Christine M.D.; Cooper, Robert M.D.; Westra, William H. M.D.; Udelsman, Robert M.D.Case Reports: PDF OnlyCase Reports: PDF Only510p 341-346