Age-related declines in dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate have been postulated to aggravate some diseases of aging. As a result, DHEA supplementation often is touted as the "fountain of youth," and it is being used widely in an unregulated fashion without evidence of efficacy or safety.
This review addresses DHEA replacement, discussing issues of bioavailability and possible beneficial effects. Safety concerns also are addressed.
At present, we believe that DHEA replacement is not suitable for widespread clinical use; however, the potential for future hormonal therapy of aging using this compound is such that further investigation certainly is warranted.
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