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00019616-199110000-00004MiscellaneousThe EndocrinologistThe Endocrinologist© Lippincott-Raven Publishers.1October 1991 p 301–312Managing the Pregnant Diabetic WomanDiabetes: PDF OnlyPeterson, Lois Jovanovic M.D.; Peterson, Charles M. M.D.Sansum Medical Research Foundation, 2219 Bath Street, Santa Barbara, CA 93105.AbstractFuel metabolism in pregnancy changes in response to the increased nutrient needs of the fetus and the mother. The flow of fuels to the fetus is mediated by the rise of diabetogenic hormones. The cascade of hormonal events in pregnancy promotes maternal glucose production and decreased peripheral glucose utilization to provide more fuel for the fetus. If there is a maternal defect in insulin secretion and glucose utilization, gestational diabetes will result. Maternal hyperglycemia, whether the result of gestational diabetes or pre-existing diabetes, is toxic to the fetus. Hyperglycemia during organogenesis increases the risk of spontaneous abortion and congenital anomaly. Hyperglycemia during growth and development of the fetus leads to the classic fetopathy of the infant of the diabetic mother: macrosomia, hypoglycemia, hypocalcemia, hyperbilirubinemia, erythremia, and respiratory distress. This article will review the etiology of hyperglycemia during pregnancy, the rationale for normalizing the glucose level during pregnancy, and a treatment protocol that has proven successful for achieving and maintaining normoglycemia during pregnancy.Managing the Pregnant Diabetic WomanPeterson Lois Jovanovic M.D.; Peterson, Charles M. M.D.Diabetes: PDF OnlyDiabetes: PDF Only41p 301-312