Special FocusPersistent Nerve Injury and CRPS After Ankle SprainsPina, Matthew MD; Messina, James MD; Geaney, Lauren E. MDAuthor Information Department of Orthopaedic Surgery, University of Connecticut, Farmington, CT L.E.G. is a paid consultant for Paragon 28. She is also a board member with the American Orthopedic Foot and Ankle Society and the Connecticut Orthopedic Society. She gets research support from Arthrex Inc. The remaining authors declare no conflict of interest. Address correspondence and reprint requests to Lauren E. Geaney, MD, UConn Health, MSI 4th Floor, 263 Farmington Avenue, Farmington, CT 06030. E-mail: [email protected]. Techniques in Foot & Ankle Surgery: March 2021 - Volume 20 - Issue 1 - p 2-5 doi: 10.1097/BTF.0000000000000314 Buy Metrics Abstract A number of patients continue to experience prolonged pain, swelling, instability, and disability after a lateral ankle sprain, which is sufficient to limit their activity. There are several conditions that are misdiagnosed as chronic lateral ligament injury. In this review, we highlight common nerve conditions, with specific attention to the peroneal nerve, and chronic regional pain syndrome that can mimic chronic lateral ligament injury and can cause persistent ankle pain after lateral ankle sprain. We also offer advice for effective diagnosis and treatment of these associated pathologies. Sprained ankle syndrome, as it has been referred to, continues to be an unsolved problem in many, but we hope to better elucidate the diagnostic and treatment dilemma in most of these patients. Level of Evidence: Diagnostic Level V. See Instructions for Authors for a complete description of levels of evidence. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.