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The Role of Platelet-rich Plasma in Charcot Foot Reconstruction

Pinzur, Michael Steven MD

Techniques in Foot & Ankle Surgery: March 2012 - Volume 11 - Issue 1 - p 13–17
doi: 10.1097/BTF.0b013e318246960c
Special Focus: Role of Platelet-Rich Plasma and rhPDGF in Foot and Ankle Surgery

Growing interest exists regarding the surgical correction of diabetes-associated Charcot foot arthropathy. These patients are complicated by morbid obesity, multiple medical comorbidities, severe osteoporosis, and impaired wound healing. Knowledge of the high complication rates for wound failure, wound infection, or mechanical failure has stimulated interest in the use of statically applied circular external fixation. This presentation deals with the potential role of pooled platelet-derived growth factors (platelet-rich concentrate) and pluripotential stem cells (bone marrow aspirate), combined with circular external fixation in the treatment of this complex patient population.

Professor of Orthopaedic Surgery, Loyola University Health System, Loyola University Medical Center, Maywood, IL

Author is consultant for Biomimetics, the maker of recombinant PDGF.

Address correspondence and reprint request to Michael Steven Pinzur, MD, Loyola University Health System, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153. E-mail:

© 2012 Lippincott Williams & Wilkins, Inc.