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Platelet-rich Plasma as a Biological Adjunct to the Surgical Treatment of Osteochondral Lesions of the Talus

Smyth, Niall A. MD; Fansa, Ashraf M. MD; Murawski, Christopher D.; Kennedy, John G. MD, FRCS (Orth)

Techniques in Foot & Ankle Surgery: March 2012 - Volume 11 - Issue 1 - p 18–25
doi: 10.1097/BTF.0b013e3182463ca1
Special Focus: Role of Platelet-Rich Plasma and rhPDGF in Foot and Ankle Surgery

Platelet-rich plasma (PRP) has become an increasingly utilized biological adjunct in orthopedics, particularly in sports medicine. Cartilage repair is one such application for which PRP has been utilized. Osteochondral lesions of the talus are common athletic injuries, and they present a difficult clinical problem in part because of the poor biological environment of cartilage healing. The current authors’ are investigating the use of PRP with reparative and restorative techniques, including arthroscopic bone marrow stimulation and autologous osteochondral transplantation, respectively. The hypothesis is that the bioactive molecules and growth factors contained within PRP will stimulate a healing response for the differentiation of fibrocartilage such that it resembles a more hyaline-like microstructure, in addition to enhancing bony incorpoaration. In addition to these anabolic pathways, there is also recent evidence to suggest that PRP may inhibit the catabolic processes of arthritis. This article presents the indications and treatment strategy for using PRP in the surgical treatment of osteochondral lesions of the talus.

Hospital for Special Surgery, New York, NY

The authors declare no conflict of interest.

Address correspondence and reprint requests to John G. Kennedy, MD, FRCS (Orth), Hospital for Special Surgery, 523 East 72nd Street, Suite 514, New York, NY 10021. E-mail:

© 2012 Lippincott Williams & Wilkins, Inc.