The Regulations and Mechanisms of Laparoscopic Sleeve Gastrectomy (LSG) for Obesity and Type 2 Diabetes: A Systematic ReviewChang, Xusheng PhD; Cai, Hui PhD; Yin, Kai PhDSurgical Laparoscopy Endoscopy & Percutaneous Techniques: December 2017 - Volume 27 - Issue 6 - p e122–e126 doi: 10.1097/SLE.0000000000000468 Online Articles: Review Article Abstract Author Information Obesity and diabetes mellitus are becoming 2 of the most leading risk factors that threaten public health worldwide. Obesity is a very strong but preventable risk factor for getting type 2 diabetes. Laparoscopic sleeve gastrectomy (LSG) has been a main approach to the surgical management of morbid obesity and type 2 diabetes but its role remains undefined. Here, we overviewed the clinical outcomes and regulatory mechanisms of LSG, aiming at providing thorough theoretical supports and effective technical guidance to the pathogenesis, prognosis, treatment and prevention of type 2 diabetes with obesity. Futher more, the prospectives and main drawbacks (such as considerable heterogeneity and unicity, little comparability and relevance) of LSG are also discussed. Department of Gastrointestinal Surgery, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China Supported by the Shanghai Municipal Planning Commission of science and Research Fund (201640017) and Natural science fund for young scholars of Jiangsu Province (BK20140095). The authors declare no conflicts of interest. Reprints: Kai Yin, PhD, Department of Gastrointestinal Surgery, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China (e-mail: email@example.com). Received June 25, 2017 Accepted August 5, 2017 Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.