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The Impact of Laparoscopic Approaches on Short-term Outcomes in Patients Undergoing Liver Surgery for Metastatic Tumors

Karagkounis, Georgios MD*; Seicean, Andreea MPH, PhD; Berber, Eren MD*

Surgical Laparoscopy Endoscopy & Percutaneous Techniques: June 2015 - Volume 25 - Issue 3 - p 229–234
doi: 10.1097/SLE.0000000000000140
Original Articles

Purpose: To compare the perioperative outcomes associated with open and laparoscopic (LAP) surgical approaches for liver metastases.

Methods: The American College of Surgeons National Surgical Quality Improvement Program database was used to identify all adult patients who underwent surgical therapy for metastatic liver tumors between 2006 and 2012 (N=7684). Patients who underwent >1 procedure were excluded. Logistic regression after matching on propensity scores was used to assess the association between surgical approaches and perioperative outcomes.

Results: A total of 4555 patients underwent open resection, 387 LAP resection, 297 open radiofrequency ablation (RFA), and 265 LAP RFA. In propensity-matched samples (over 95% of patients successfully matched), there was no significant difference between LAP resection and LAP RFA in perioperative complications and length of stay and both compared favorably with their open counterparts.

Discussion: Minimally invasive approaches for secondary hepatic malignancies were associated with improved postoperative morbidity and length of stay and should be preferred in appropriate patients.

*Department of General Surgery, Cleveland Clinic

Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH

The authors declare no conflicts of interest.

Reprints: Georgios Karagkounis, MD, Department of General Surgery, Cleveland Clinic Main Campus, 9500 Euclid Avenue/F20, Cleveland, OH 44195 (e-mail:

Received September 2, 2014

Accepted January 22, 2015

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.