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Gastric Cancer Following Bariatric Surgery: A Review

Orlando, Giulio MD*; Pilone, Vincenzo MD; Vitiello, Antonio MD; Gervasi, Rita MD*; Lerose, Maria A. MD*; Silecchia, Gianfranco MD§; Puzziello, Alessandro MD

Surgical Laparoscopy, Endoscopy & Percutaneous Techniques: October 2014 - Volume 24 - Issue 5 - p 400–405
doi: 10.1097/SLE.0000000000000050
Review Articles
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Background: Bariatric procedures can induce a massive weight loss that lasts for >15 years after surgery; in addition, they achieve important metabolic effects including diabetes resolution in the majority of morbidly obese patients. However, some bariatric interventions may cause gastroesophageal reflux disease and other serious complications. The aim of our study is to evaluate the risk of cancer after bariatric surgery.

Methods: We conducted a review of the literature about the cases of gastric cancer arising after any bariatric procedure, including a case of adenocarcinoma incidentally discovered by the authors 6 months after laparoscopic adjustable gastric banding.

Results: Globally, 17 case reports describing 18 patients were retrieved, including the case study by the authors. The diagnosis of tumor was at a mean of 8.6 years after bariatric surgery, 9.3 years after RYGB, and 8.1 years after restrictive procedures. The adenocarcinoma represented most cases (15 patients, 83%). In the patients with RYGB, the adenocarcinoma was localized in the excluded stomach in 5 patients (83%) and in the pouch in 1 patient (17%). After a restrictive procedure, the cancer was localized in the pouch in 5 patients (62.5%), in the pylorus in 2 patients (25%), and in lesser curvature only in 1 patient (12.5%).

Conclusions: There is a lack of evidence about a connection between the late occurrence of gastric adenocarcinoma and the bariatric surgery. For this reason, although the preoperative upper endoscopy is still mandatory, there is no need for a regular endoscopic evaluation of patients after surgery.

*Department of Surgery, University Magna Graecia, Catanzaro

Department of Medicine and Surgery, University of Salerno, Salerno

Department of Internal Medicine and Surgery, University “Federico II” of Naples, Naples

§Department of Medico-Surgical Sciences and Biotechnologies, Division of General Surgery, “La Sapienza” University of Rome, ICOT, Latina, 00185, Italy

The authors declare no conflicts of interest.

Reprints: Gianfranco Silecchia, MD, Department of Medico-Surgical Sciences and Biotechnologies, Division of General Surgery, “La Sapienza” University of Rome, ICOT, Latina, 00185, Italy (e-mail: gsilecchia@jumpy.it).

Received November 3, 2013

Accepted January 4, 2014

© 2014 by Lippincott Williams & Wilkins