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Commentary

Is It Time to Stop Using Single-dose Oral Metronidazole for the Treatment of Trichomoniasis in Women?

Muzny, Christina A. MD, MSPH*; Richter, Saralyn RN*; Kissinger, Patricia PhD

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Sexually Transmitted Diseases: May 2019 - Volume 46 - Issue 5 - p e57-e59
doi: 10.1097/OLQ.0000000000000959
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Trichomonas vaginalis is the most common curable, nonviral sexually transmitted infection (STI) worldwide.1 It is associated with multiple adverse outcomes including premature rupture of membranes, preterm birth, low birthweight infants, infertility, and increased risk of human immunodeficiency virus (HIV) acquisition.2–5 Despite its high prevalence and substantial morbidity, it is considered a neglected STI6–8 due to a limited public health response.9–11

Per the 2015 Centers for Disease Control Sexually Transmitted Disease (CDC STD) treatment guidelines,12 first-line treatment for trichomoniasis in HIV-negative women and men includes a single 2-g dose of oral metronidazole (MTZ) or tinidazole. Oral MTZ 500 mg twice daily for 7 days is an alternative therapy. These recommendations were based on several small trials conducted over 30 years ago that found no difference between the 2 doses but were not powered for equivalency. A meta-analysis of these studies showed that women receiving the 7-day regimen of oral MTZ were 50% less likely to be positive at test of cure compared with those receiving a single dose.13 In addition, a prior randomized controlled trial (RCT) of HIV-infected women with T. vaginalis found that the 2-g dose of oral MTZ was less effective than 7 days.14 High rates of concurrent bacterial vaginosis (BV) may be 1 factor interfering with single-dose therapy, as the vaginal environment associated with BV may partially protect T. vaginalis from the effects of single-dose MTZ.15 Thus, it is recommended to treat HIV-infected women with trichomoniasis with 7 days of oral MTZ, which also treats BV.12 However, it is important to note that this recommendation is independent of BV status.

We recently conducted an RCT of the single 2-g dose of oral MTZ versus the 7-day dose for treatment of trichomoniasis in HIV-uninfected women.16 Of 623 women randomized, those in the 7-day arm had 45% fewer treatment failures than those receiving the single dose. In contrast to the prior RCT in HIV-infected women,14 risk for T. vaginalis at test of cure was similar by BV status in this study. Self-reported medication adherence was greater than 95% in both arms. We concluded that the 7-day regimen of oral MTZ should be the preferred treatment for trichomoniasis among HIV-negative women.

The implications of this RCT prompted us to write this commentary to readers of the Sexually Transmitted Diseases journal, the official publication of the American STD Association, as many are thought leaders with expert opinions in this field. In particular, should the next version of the CDC STD treatment guidelines be changed to recommend the 7-day oral MTZ regimen as the first-line treatment regimen for all women with trichomoniasis? Will adherence with the 7-day regimen become an issue “in the real world” if this becomes the preferred treatment? How will a change to the 7-day regimen in women impact the treatment of men with T. vaginalis or who are a contact to a female partner with T. vaginalis, as men are still receiving the single 2-g dose of oral MTZ? Also, how will this change impact expedited partner therapy (EPT) of trichomoniasis, as it is currently permissible in the majority of US states?17 These discussions recently came up at our monthly meeting with physician colleagues at our local health department STD clinic in Birmingham, AL, and there were no easy answers. Our STD clinic sees a large number of HIV-negative T. vaginalis–infected women and men (primarily African American)18 and is currently providing the single 2-g oral MTZ dose for therapy for HIV-negative women and men with trichomoniasis per standing orders.

In addition to better efficacy than single-dose MTZ in our recent RCT, another reason advocating for a change in the preferred treatment regimen for T. vaginalis–infected women to 7 days is the large, ongoing burden of T. vaginalis infection among US women. According to the most recent National Health and Nutrition Examination Survey data (2013–2014 cycle), T. vaginalis infection prevalence was 1.8% among US women ages 18 to 59 years.19 It was almost 5 times higher among US African American women (8.9%), signifying a pronounced racial disparity that continues to exist. Further interventions are needed to reduce this high and disproportionate burden of T. vaginalis infection, particularly in African American women, one of which could be more highly efficacious treatment. Although our RCT had several limitations (enrollment was lower than planned and the study population consisted mainly of symptomatic African American women from urban areas), we do not believe that these limitations would dampen enthusiasm for a change in guidelines.

On the other hand, one could argue that treatment adherence could become a problem if the 7-day regimen becomes the preferred regimen. The 2-g oral MTZ dose is attractive as it can be given to patients as directly observed therapy. In contrast, the 7-day regimen will require patient adherence over a period of time. Nonadherence to medication is well known to lead to decreased treatment effectiveness and potential worsening of a patients' condition.20 With respect to STIs, this could lead to ongoing STI transmission and drug resistance. Treatment adherence was high and not significantly different between arms in our recent T. vaginalis RCT16 and in the prior T. vaginalis RCT of HIV-infected women.14 However, these were highly controlled clinical trials in which participants received monetary compensation and were not ‘real world’ situations, as mentioned by Keizur and Klausner21 in their editorial to our RCT. In a study of 91 predominately African America women prescribed multidose oral therapies for pelvic inflammatory disease, participants took approximately 70% of their twice daily doses, took the medications for less than half of their outpatient days, took an unscheduled drug holiday almost 25% of the time, and took only 16.9% of their doses within the optimal timing interval.22 In light of these suboptimal treatment adherence rates, data on patient adherence to the 7-day oral MTZ regimen for trichomoniasis in “real world” situations is needed. The most logical population in which to obtain these data is HIV-infected women with trichomoniasis, as guidelines currently recommend the 7-day oral MTZ dose.12

Another issue that will arise if providers change to the 7-day oral MTZ regimen is how will this impact the treatment of men who are their sexual contacts and who are diagnosed with T. vaginalis? Will we continue to treat them with the single 2-g dose of oral MTZ? To our knowledge, an RCT comparing the efficacy of the single 2-g dose of oral MTZ with the 7-day regimen for trichomoniasis in men has not been conducted; our recent RCT only included women. And how would the spontaneous resolution of trichomoniasis in men factor into this situation? In an RCT of nongonococcal urethritis treatment among men,23 11 (69%) of 16 not receiving treatment for trichomoniasis had apparent spontaneous resolution of their infection during follow-up. Also, from a practical standpoint, if a woman is treated with the 7-day regimen but her male partner(s) are treated with the single 2-g dose, there could be a conflict in the timing of abstinence from sex, which could put the couple at risk for reexposure. These questions should be taken into consideration when counseling patients on T. vaginalis treatment.

Enhanced counseling messages should be provided to women receiving the 7-day oral MTZ dose to try to head off these potential issues. Counseling messages should include the need to take the entire 7 days of medication (preferably with nondairy foods such as crackers to reduce nausea and vomiting), use cell phone alarms to set medication reminders, do not share the medication, and do not have sex until both the patient and her partner(s) have been treated. Anecdotally, there is an additional issue that has come up in our HIV clinic practice. Women receiving the 7-day regimen for a current episode of trichomoniasis may know that in the past a single 2-g dose of oral MTZ was used. Because of this, they may take a single 2-g dose when given the 7-day dose. They may share also their medication with their partner(s), because there are 3 possible 2-g doses in a 7-day pill bottle. Enhanced counseling services should be provided to women receiving the 7-day oral MTZ regimen to try to avert this potential issue.

Finally, how will changing to the 7-day oral MTZ treatment regimen in all women with trichomoniasis impact EPT in states allowing this practice? While most states allow for EPT, uptake has been relatively low for chlamydia and gonorrhea.24,25 It is currently unclear how often EPT is prescribed for partners of patients with trichomoniasis. Moving forward, should providers give women the 7-day oral MTZ regimen for their male partner(s)? And what about female sexual partners? These important topics should be addressed in the next version of the CDC STD treatment guidelines.

In conclusion, new RCT data strongly suggest that the 7-day oral MTZ regimen should be the preferred T. vaginalis treatment regimen in all women. We advocate for this change in the next version of the CDC STD treatment guidelines. However, this change must be accompanied by effective counseling messages that describe how to mitigate the side effects of oral MTZ and stress the importance of adherence to therapy and partner treatment.

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