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Linkage and Referral to HIV and Other Medical and Social Services: A Focused Literature Review for Sexually Transmitted Disease Prevention and Control Programs

Carter, Marion W. PhD*; Wu, Hsiu MD; Cohen, Stephanie MD, MPH; Hightow-Weidman, Lisa MD, MPH§; Lecher, Shirley Lee MD, MPH; Peters, Philip J. MD

doi: 10.1097/OLQ.0000000000000290
Review

Background Sexually transmitted disease (STD) program and clinic staff play an important role in providing linkage and referrals to programs and services that address the complex medical and psychosocial needs of their clients. We synthesized recent published literature related to effective practices for linkage to care for HIV and referral to other medical and social services.

Methods Three PubMed searches were conducted to identify relevant studies published since 2004 on (1) linkage to HIV care, (2) referral within STD clinical contexts, and (3) (review articles only) referral practices among all medical specialties. Systematic review procedures were not used.

Results Thirty-three studies were included in this review. Studies highlight the limited value of passive referral practices and the increased effectiveness of active referral and linkage practices. Numerous studies on linkage to HIV care suggest that case management approaches, cultural-linguistic concordance between linkage staff and clients, and structural features such as colocation facilitate timely linkage to care. Integration of other medical and social services such as family planning and alcohol screening services into STD settings may be optimal but resource-intensive. Active referral practices such as having a written referral protocols and agreements, using information technology to help transfer information between providers, and making appointments for clients may offer some benefit. Few studies included information on program costs associated with linkage and referral.

Conclusions Recent literature provides some guideposts for STD program and clinical staff to use in determining their approach to helping link and refer clients to needed care. Much experience with these issues within STD services remains unpublished, and key gaps in the literature remain.

From the Divisions of *STD Prevention and †HIV/AIDS Prevention, CDC, Atlanta, GA; ‡San Francisco Department of Public Health, San Francisco, CA; and §School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC

Acknowledgment: The authors thank Elizabeth Gerndt, Emory University MPH candidate, for her assistance with parts of this review. They also appreciated comments from Dayne Collins, Tom Peterman, and Dawn Broussard during manuscript preparation. The findings of this report are those of the authors and not the official position of the Centers for Disease Control and Prevention.

Conflicts of interest and sources of funding: None declared.

Correspondence: Marion Carter, PhD, Division of STD Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS-E-80, Atlanta, GA 30333

Received for publication February 6, 2015, and accepted March 31, 2015.

State and local health department sexually transmitted disease (STD) programs and STD clinics have long served as gateways to other health and social services for their clients. In the area of HIV, clinical guidelines have recommended testing STD patients for HIV for decades, and many new HIV cases have been identified in STD clinical settings.1 Among all sites receiving the Centers for Disease Control and Prevention (CDC) support for HIV testing in 2011, for example, STD clinics conducted 19% of tests done in health care settings and identified 26% of all new HIV cases.2 Partner services guidelines also recommend testing sex partners of STD patients for HIV infection.3 As a result, STD clinical settings and programs have an important role in the HIV care continuum by diagnosing HIV infection, actively linking those individuals to HIV care, and helping those who have fallen out of care to reengage. This work directly affects collective progress toward national goals for HIV/AIDS, related to linkage to HIV care and viral suppression.4 Moreover, individuals who are negative for HIV but who are at high risk for HIV infection may be referred or linked to HIV prevention services, including postexposure and preexposure prophylaxis (PrEP).5

Most STD programs and clinics regularly encounter clients with other important health needs. Patients who seek care at STD clinics are at higher risk for unintended pregnancy, substance abuse, mental health issues, unstable housing, and interpersonal violence.6–10 In addition, those that seek care from publicly funded STD clinics have lower rates of health insurance coverage.11 Partners of STD patients who are encountered in the course of STD program partner services may also have similar needs.

We provide a review of published literature related to interventions intended to support linkage and referral to HIV care and treatment, and other clinical and social services. We highlight linkage to HIV care, given the documented public health benefit of linkage to care for HIV and increasing centrality of this role to both HIV and STD programs. The objective is to offer lessons based on current literature to help STD program and clinical staff decide whether and how to best develop and support those systems and interventions.

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METHODS

Selective (not systematic) literature reviews on linkage and referral were performed. For studies related to linking persons newly diagnosed with HIV to care, we conducted searches in PubMed using the terms including “HIV,” “linkage,” “linkage to care,” and “referral and consultation.” Only studies conducted in the US published after 2004 were included for that section of the review. For studies about linkage and referral to other medical and social services, we conducted 2 searches in PubMed. The first search used terms such as “STD” combined with “referral” and “linkage” to identify published studies of referrals that were implemented in STD clinical or program settings. The second search involved identifying review articles published since 2004 related to linkage and referral to care, using various Medical Subject Heading and free-text terms such as “care coordination,” “patient navigation,” and “referral.” The review articles could pertain to any medical specialty.

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RESULTS

Linkage HIV Care: Identifying Who Is in Need

Sexually transmitted disease staff routinely encounter persons living with HIV during clinical visits and in the course of providing partner services. These encounters offer direct opportunities to identify those who may benefit from linkage to HIV care.12 However, HIV testing and care status are not always readily available, requested, or disclosed. Increasingly, clinicians and program managers are able to monitor linkage to, and retention in, HIV care within HIV surveillance systems and electronic medical records.13 For example, a bidirectional public health information exchange, linking surveillance data with electronic medical record data to facilitate linkage or reengage patients to care, has been implemented in Louisiana. The Louisiana Public Health Information Exchange alerts medical providers when individuals with HIV/AIDS who have not received HIV care for more than 12 months are seen at facilities in an integrated network. During February 2009 to January 2011, Louisiana Public Health Information Exchange generated 488 alerts and identified 345 HIV-positive patients, of which 82% had at least 1 CD4 or HIV viral load test over the follow-up period indicating likely reengagement in HIV care14 (see also Zetola et al.15). Although many STD programs and clinics are still unable to access to HIV status and care information on their patients, these examples suggest that the capacity to do so is growing and that the effort is worthwhile.

Identifying barriers that prevent linkage to HIV care is important to help optimize HIV linkage practices. Table 1 summarizes barriers documented across a range of studies and offers examples of program components that could reduce those barriers. Barriers can occur at various levels, some on the individual level, related to psychosocial characteristics such as low health literacy or low self-efficacy to seek care, whereas others relate to socioeconomic status, such as lack of transportation or health insurance, and complexity of the US health care system.16–18

TABLE 1

TABLE 1

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Linkage to HIV Care: Supporting the Process

Few systems for linkage to care can overcome all potential barriers to care, but several studies suggest ways to facilitate linkage. A recent systematic review summarized outcomes associated with a number of interventions to promote linkage to, as well as utilization of, HIV care.24 Below, we briefly highlight the studies included in that review related to linkage to care and combine those with results from other studies that highlight programmatic aspects of particular relevance to STD program and clinical contexts. Table 2 provides a snapshot of those studies that tested linkage interventions in prospective study designs.

TABLE 2

TABLE 2

One strategy associated with increased linkage to care is active referral. Many studies have shown that referral by a tester who makes the treatment appointment or accompanies the patient to an appointment increases the likelihood of linkage, compared with passive referral (e.g., only providing written material).19,20,22,26 In one study, when the provider who provided the positive HIV test result actively referred the patient to care by calling to make the appointment, a higher proportion of patients were linked to care early (≤30 days), compared with those who did not have this service provided at the time of testing.28

Provision of case management has also been shown to be associated with increased linkage to care. For example, the Antiretroviral Treatment and Access Study (ARTAS-I) evaluated entry into and retention in care as part of a multisite randomized controlled trial in the United States comparing strengths-based case management sessions (up to 5 in a 90-day period) vs passive referrals for local care among patients with recently diagnosed HIV infection.25 Grounded in principles of empowerment and self-efficacy, trained social workers helped clients to identify their internal strengths and assets to facilitate successful linkage to HIV medical care. Compared with participants who received passive referral (only receiving informational pamphlets about HIV and local resources), a significantly higher proportion of the participants who received the strengths-based case management intervention visited an HIV clinician at least once within 6 months (78% vs 60%) and had at least 2 visits in the first 12-month period (64% vs 49%). The ARTAS intervention cost was approximately $1171 per client and $7807 per additional client linked to care over the standard of care (2002 dollars). With improvements in efficiency (e.g., increasing the case manager workload to 10 clients per month), the authors suggest that the cost of the ARTAS intervention could be reduced to an estimated $599 per client and $3393 per additional client linked to care. The ARTAS-II study demonstrated the effectiveness of the ARTAS 10 health department and community-based organization settings23 Even among hard-to-reach populations, case management strategies seem to be beneficial, although they may be resource-intensive.27

Studies also highlight the relevance of characteristics or skills of the person providing support for linkage to care. High cultural and linguistic concordance between patients and project staff has been associated with successful linking to medical care.27 In a study examining successful linkage to HIV care models used in hospital emergency departments (EDs), health department outpatient clinics, and other non–primary care providers, researchers found that cultural and linguistic concordance between staff and patients as 1 of 4 core components of successful linkage to care protocols.22 In a different study of people newly diagnosed with HIV in select San Francisco clinical settings, being interviewed by a public health Disease Intervention Specialist (DIS) was associated with an 18-fold increased likelihood of being linked to care, compared with those not interviewed, adjusting for other patient and referral site characteristics.15 This association may relate, in part, to the unique skill set that many DIS use to motivate and support access to care.

Finally, structural or system characteristics also have been associated with improved linkage. For example, at HIV care clinics, longer delays to schedule a new patient visit were associated with greater likelihood of non-attendance.30 In a study in an ED setting, among patients who received a preliminary positive rapid HIV result, patients who met with a linkage to care team within 1 business day achieved a 90% linkage to care rate within 90 days. This study emphasized that the HIV linkage to care process can be initiated before finalization of all confirmatory HIV test results, which can be delayed for weeks and unnecessarily interrupt the linkage process.22,31,32 1The presence of explicit linkage procedures and protocols may also make a difference. In a study that found that linkage to care for newly diagnosed individuals was significantly lower among patients identified in an STD clinic compared with the county hospital, the authors proposed that the recent implementation of a multidisciplinary program at the hospital for patients newly diagnosed as having HIV may have accounted for this difference.15 Finally, in another study designed to evaluate structural factors that impact linkage to care, those HIV testing sites colocated with HIV primary care clinics had a higher proportion of clients link to care within 6 months compared with non-colocated sites (87% vs 73%).33

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Integration of Other Medical and Social Services in STD Clinical Settings

Many STD service providers are faced with trying to address a range of issues that extend beyond the immediate STD- or HIV-related concerns clients have. Colocation of these other clinical and social services and even service integration are optimal in most cases, as it greatly simplifies referral and linkage. Two examples from STD clinical settings involve integration of reproductive health care, specifically family planning34 and preconception health.35,36 As those studies show, although integration brings numerous potential benefits to clients, it may require significant changes to a clinic's practices. For example, integrating comprehensive family planning services into a large STD clinic involved adding prompts to the electronic medical record system, modifying the client and visit record, and creating new patient pathways through the clinic, among other changes. They estimated that compared with visits only involving STD services, the total cost per visit rose by $29.25.34

We also identified 2 studies that described the experience of incorporating limited screening and referral services for substance abuse into STD clinical settings. Yu and colleagues21 showed that integrating screening and a brief motivational intervention for substance abuse in an STD clinic setting for the purpose of making referrals for appropriate treatment elsewhere required significant time and resources, including hiring a substance abuse interventionist staff person. However, they concluded their pilot effort showed that this was both feasible and acceptable to patients (e.g., >85% of patients involved indicated that the sessions were helpful overall and endorsed the strategy; no outcome data were reported). A recent trial from the UK tested the effectiveness of integrating clinician-delivered brief advice and referral to an on-site Alcohol Health Worker (AHW), who then provided more in-depth consultation and referral to external services, for attendees at 3 sexual health clinics who reported high levels of drinking.37 They found that although nearly all participants received advice from a clinician and referred to the AHW, only 20% spoke with the AHW. Although relatively inexpensive to implement, this intervention that provided universal screening for excessive alcohol use and related clinician-delivered advice did not lead to a significant reduction in alcohol use or unprotected sex. The authors concluded that it did not warrant continuation or roll-out.

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Referrals

The concept of referral is similar to that of linkage to care, and the terms are sometimes used interchangeably a hand-off of a patient or client to another service. The term linkage is somewhat new and specific to HIV and serves to convey a greater focus on the outcome, rather than the process. There is a long history of research on referrals within the health care system that is relevant to linkage to HIV and other care and services. Therefore, we also summarized recent review articles on referral from primary care to specialty care, or from the ED to other care settings. The limited search (see “Methods”) identified seven relevant review articles, including one Cochrane review.38–44

This set of articles highlights 3 main points. First, referral patterns are problematic across many parts of the health care system, including issues with both overreferral and underreferral.43 Second, they provide helpful ways of conceptualizing referral and linkage systems, for example by outlining barriers that can operate on the patient level (e.g., lack of interest in referral on the part of the patient), provider level (e.g., a lack of training in making referrals and relevant follow-up), systems level (e.g., absence of protocols and technology to facilitate information exchange), community level (e.g., absence of appropriate referral sites), and policy level (e.g., lack of financial reimbursement for time spent making and following up on referrals).39,41,43,44

Third, research from non-STD/HIV fields also lends further support to the concept that passive approaches, whereby the referring provider recommends a referral without additional support or follow-up, are unlikely to be effective.38,39,43 Referral protocols that include guidelines and structured referral sheets as well as those that involve explicit engagement with the providers being referred to have been more successful. In a review of ED referrals, developing post-ED treatment plans and making appointments on the patient's behalf while still in the ED seemed to effectively increase referrals completed.40 Several studies point to technology and health information systems as a promising means of reducing some barriers within the referral process, particularly those related to communication gaps between referral sites and the ability to assess whether follow-up occurred.39,40,43 However, the authors of many review articles agreed that there is surprisingly little research on interventions to improve referral systems in general, given its importance to patient care and costs.38,40–43

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Referral to Health Insurance

Facilitation of health insurance enrollment or coverage is a unique issue that is relevant to many STD programs. Access to health insurance helps address the significant cost barriers that can undermine most referral and linkage systems. This role has heightened with recent opportunities to increase access to health insurance through the Affordable Care Act. Support for health insurance navigators or certified application counselors has expanded, and although the exact scope of involvement of STD program and clinic staff in this movement is unknown, it is well justified. Not only do STD programs directly work with populations more likely to lack adequate coverage (e.g., low-income populations),11 but also STD clinical settings are increasing their capacity for billing for services, thereby further incentivizing them to support insurance enrollment of their own patients.45 Partnerships and colocation with community and other health care centers with established infrastructure for insurance counseling and enrollment further support this function. At a minimum, STD clinics and program staff, including DIS, can offer basic education to patients about their health coverage options and refer people to others who are trained to help people screen for and enroll in coverage. The insurance context, eligibility rules, and program characteristics differ across states, and STD program staff should be aware of some of these features.46,2

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DISCUSSION

Sexually transmitted disease program and clinic staff have always played an important role in providing linkage and referrals to programs and services that address the complex medical and psychosocial needs of their patients and clients. The aim of this review was to synthesize recent published literature related to linkage to care for HIV and other medical/social services, to provide STD program staff with additional information to use in planning their approaches.

For linkage to HIV care, current evidence summarized here and in a recent systematic review24 suggests that an optimal linkage protocol might include the following:

  • active referral by making the treatment appointment and/or accompanying the patient to the HIV care clinic;
  • appointment coordination by making the treatment appointment as soon as possible with an HIV care provider that is ideally either colocated or conveniently located for the patient (this appointment should ideally occur within several days of preliminary diagnosis);
  • hiring patient navigators or linkage workers to focus specifically on linkage;
  • short-term strengths-based case management; and
  • ensuring the best possible linguistic and cultural concordance between linkage staff and patients.

Providing intensive individual-level linkage support requires resources and, for many STD programs, partnerships with HIV care agencies and providers. For example, using the ARTAS model of short-term strengths-based case management, the cost is estimated to be $599 per client.25 Implementing the full optimal package that includes all of the components described earlier would add additional costs, in additional to substantial staff training and oversight. Forging partnerships and defining roles among relevant public health agencies, health care providers, and nongovernment agencies to support linkage to care processes can be complicated as well. However, those investments must be weighed against the potential individual and community costs of persons delaying HIV care and antiretroviral treatment and in comparison with costs used to promote expanded HIV testing.47,48 Opportunities and support for strengthening those partnerships are expanding.3

Much research has focused on linking patients newly diagnosed with HIV to care, but similar services also benefit people who fall out of care. Sexually transmitted disease programs and clinical services encounter such persons and thus should accommodate their linkage procedures to serve both newly diagnosed and previously diagnosed persons.12 Procedures may need to be adapted or intensified further to address the various reasons that lead people to fall out of care. Comprehensive and tailored support may be essential for them to reengage successfully. Future research and evaluation should continue to examine best practices for linkage to HIV care for both newly diagnosed and previously diagnosed individuals and better determine how those programs and services should differ for those 2 groups.

Linkage to PrEP is another promising area for service expansion. Recent CDC guidelines recommend consideration of PrEP as an effective biomedical intervention to reduce the risk of HIV infection acquisition in high-risk, HIV-negative individuals.5 Initial uptake of PrEP has been slow,49 and various barriers to prescribing and using PrEP remain (e.g., concerns about patient adherence, the possibility of increased sexual risk behaviors, and costs, among others).50 However, the potential for growth is high, particularly in STD services that routinely interact with eligible persons. Use of PrEP begins with eligibility screening that aligns well with the sexual history and other assessments already done in most STD clinical settings and as part of many partner services evaluations. Given that initiation and use of PrEP involves ongoing laboratory testing, appointments with an experienced medical provider, and adherence and prevention counseling,5 Preexposure prophylaxis could be integrated into STD clinical settings as well. A PrEP demonstration project conducted in 2 STD clinics and a community health center demonstrated high PrEP uptake (60% of eligible patients started PrEP) and a high level of adherence (77% of patients on PrEP had a tenofovir diphosphate level consistent with taking at least 4 doses/wk at their 4-week study visit).51,52 As PrEP usage expands across clinical and community settings, best practices for providing effective referral and linkage in various program contexts, as well as alternative models of service integration, should be documented and evaluated.

Multicomponent linkage services would be optimal for helping to link patients and their partners to other (non-HIV) medical and social services; however, in those cases, the cost-effectiveness may more uncertain. For that and other reasons, implementation of high level support to link patients or partners reporting drug or alcohol abuse or mental health issues to relevant services and assure uptake of those services may be impractical in many STD clinic settings. In those cases, less intensive linkage or referral systems may be the best option. Given that previous research points to the minimal effectiveness of passive referral practices, programs should consider using active referral practices, such as

  • helping to make an appointment for a patient;
  • sending information about a patient to the referral provider;
  • having written, standardized referral procedures in place;
  • involving referral providers in the development of such procedures and maintaining substantive partnerships with key referral agencies; and
  • use of information technology to facilitate all parts of a referral process including ensuring that the referral was completed.

This review is subject to various limitations. Systematic review procedures were not used, and thus, relevant studies may have been missed. Among studies focused on linkage to care for newly diagnosed persons with HIV, only one randomized study was identified. Few studies across those reviewed here included discussion of the program costs associated with various linkage and referral practices. Moreover, publication bias in favor of those finding positive associations also likely affected this review; important lessons from interventions that did not increase linkage to care or referrals were probably underrepresented. All of these factors limit the ability of STD and other programs to translate published findings into action.

All STD programs and clinical settings engage in referrals and linkage to other health care settings to some extent. A wealth of program experience with referrals and linkage systems remains unpublished and would complement these findings. What other models or approaches are being tried? What roles should STD program staff play toward facilitating linkage to HIV care? To other medical and social services, including health care coverage? What kinds of partnerships with other public health agencies and providers would maximize both resources and patient experiences, to get the care they want or need? For a system characterized by limited resources and a wide variety of program contexts, the answers are not clear. Nevertheless, given the importance of care coordination to public health and health care, further discussion, evaluation, and dissemination of those experiences are vital.

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1 Recognizing the benefit from quick linkage to ongoing HIV care and prevention services, the Ryan White HIV AIDS Program has published a memo emphasizing that patients with a positive result from a rapid HIV test can be linked to care at a Ryan White HIV AIDS Program–funded clinic before confirmatory HIV test results have returned: http://hab.hrsa.gov/files/hrsacdchivtestingletter2013.pdf.
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2 STD staff in particular should understand the unique challenges that expanded eligibility for insurance means for people needing or in HIV care, as the role of Ryan White services transitions toward more “wrap-around” services and reduces its role in funding direct clinical care.
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3 For example, the HRSA-CDC “Partnerships for Care (P4C)” project supports health departments and health centers to jointly work together to improve HIV health outcomes, including linkage to care, http://www.hrsa.gov/grants/apply/assistance/bphchiv/. The Centers for Disease Control and Prevention's effective interventions Web site provides various tools for implementing ARTAS: http://www.effectiveinterventions.org/en/HighImpactPrevention/PublicHealthStrategies/ARTAS.aspx.
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