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Syphilis-Associated Acute Renal Failure and Hepatitis in the Setting of Human Immunodeficiency Virus Coinfection

Sciaudone, Michael MD; Rutstein, Sarah E. MD, PhD; Farel, Claire E. MD, MPH

doi: 10.1097/OLQ.0000000000001062
Case Reports

Two individuals with human immunodeficiency virus presented in acute renal failure with nephrotic range proteinuria and were diagnosed with secondary syphilis. One of them also had elevated transaminases. Kidney biopsies revealed membranous nephropathy, a rare complication of secondary syphilis, in both cases. Normal hepatic and renal function were restored after treatment with penicillin.

In the context of increasing rates of primary and secondary syphilis, clinicians will be more likely to encounter unusual manifestations of this disease. Here, we describe 2 patients with syphilitic nephropathy, one of whom had concomitant hepatitis.

From the Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC

Conflicts of interest: None declared.

Sources of Funding: Support for this work was provided by the University of North Carolina at Chapel Hill Center for AIDS Research, an NIH-funded program (grant award P30 AI50410).

Correspondence: Claire E. Farel, MD, MPH, 130 Mason Farm Rd, CB 7030 Chapel Hill, NC 27514. E-mail:

Received for publication July 10, 2019, and accepted August 25, 2019.

Online date: October 29, 2019

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