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Association of Sexually Transmitted Diseases With Cervical Ectopy

A Systematic Review

Soares, Leila Cristina MD, PhD; Braz, Fernanda Lehrer Turbae Amaral MD; Araújo, Amanda Rodrigues MD; Oliveira, Marco Aurélio Pinho MD, PhD

Sexually Transmitted Diseases: July 2019 - Volume 46 - Issue 7 - p 452–457
doi: 10.1097/OLQ.0000000000000992

Objective The aim of this study was to review the available literature to explore evidence indicating an association between cervical ectopy and sexually transmitted diseases, which could help in the decision to treat or not to treat this condition.

Methods A review of the literature was conducted using the PubMed, EMBASE and databases on ectopy of the cervix using the terms “ectopy OR ectropium AND cervix” filtered only by language, without limit of date. A total of 71 studies were found in the initial selection, of which 56 were deleted by title, abstract, or full text. The remaining 15 articles were analyzed in this study.

Results Cervical ectopy showed a positive association with human papillomavirus, human immunodeficiency virus, bacterial vaginosis, cervical epithelial atypia, postcoital bleeding, and desquamative inflammatory vaginitis. High-quality studies reported no association between ectopy and chlamydia infection. It was also not associated with gonococcal infection and herpes simplex.

Conclusions Cervical ectopy shows a probable association with increased acquisition of some sexually transmitted diseases. Additional studies are required to confirm the possible beneficial effects of treatment and to evaluate the possible complications of these treatments.

Cervical ectopy shows a probable association with increased prevalence of some sexually transmitted diseases which justifies considering the treatment for this condition.

From the Gynecology Department, Rio de Janeiro State University, Rio de Janeiro, Brazil

Conflicts of Interest and Sources of Funding: none declared.

Correspondence: Leila Cristina Soares, MD, PhD, Gynecology Department, Rio de Janeiro State University, Av 28 de Setembro, 75-5° Andar Vila Isabel, Rio de Janeiro, Brazil. E-mail:

Received for publication December 2, 2018, and accepted February 25, 2019.

Online date: March 26, 2019

© Copyright 2019 American Sexually Transmitted Diseases Association