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Characteristics Associated With Human Immunodeficiency Virus Transmission Networks Involving Adolescent Girls and Young Women in Human Immunodeficiency Virus Prevention Trials Network 068 Study

Stoner, Marie C.D., PhD*; Dennis, Ann M., MD; Hughes, James P., PhD‡§; Eshleman, Susan H., MD, PhD; Sivay, Mariya V., PhD; Hudelson, Sarah E., BS; Grabowski, M. Kate, PhD; Gómez-Olivé, F. Xavier, PhD∥**; MacPhail, Catherine, PhD∥††‡‡; Piwowar-Manning, Estelle, MT (ASCP); Kahn, Kathleen, MD, PhD∥**§§; Pettifor, Audrey, PhD*∥¶¶

Sexually Transmitted Diseases: May 2019 - Volume 46 - Issue 5 - p e46–e49
doi: 10.1097/OLQ.0000000000000954

We combined behavioral survey data from the human immunodeficiency virus (HIV) Prevention Trials Network 068 study with phylogenetic information to determine if cluster membership was associated with characteristics of young women and their partners. Clusters were more likely to involve young women from specific villages and schools, indicating some localized transmission.

Supplemental digital content is available in the text.

We identified HIV phylogenetic clustering among young women in South Africa and determined that viral cluster membership was associated with village, school, and wealth, but not with other characteristics.

From the *Carolina Population Center,

Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC;

Department of Biostatistics, University of Washington;

§Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD;

MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa;

**INDEPTH Network, Accra, Ghana;

††School of Health and Society, University of Wollongong, NSW, Australia;

‡‡Wits Reproductive Health and HIV Research Institute, University of the Witwatersrand, South Africa;

§§Epidemiology and Global Health Unit, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; and

¶¶Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC

Conflicts of Interests and Source of Funding: Funding support for the HPTN was provided by the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute of Mental Health (NIMH), and the National Institute on Drug Abuse (NIDA) of the National Institutes of Health (NIH; award numbers UM1AI068619 [HPTN Leadership and Operations Center], UM1AI068617 [HPTN Statistical and Data Management Center], and UM1AI068613 [HPTN Laboratory Center]. The study was also funded under R01MH087118 and R24 HD050924 to the Carolina Population Center. Additional funding was provided by the Division of Intramural Research, NIAID, and NIH. The Agincourt Health and Socio-Demographic Surveillance System is supported by the School of Public Health University of the Witwatersrand and Medical Research Council, South Africa, and the UK Wellcome Trust (grants 058893/Z/99/A; 069683/Z/02/Z; 085477/Z/08/Z; and 085477/B/08/Z). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. We have no conflicts of interest to declare.

Correspondence: Marie Stoner, PhD, 123 W Franklin St., Chapel Hill, NC 27599–7435. E-mail:

Received for publication September 26, 2018, and accepted November 18, 2018.

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