Gyrase A genotyping reliably predicts Neisseria gonorrhoeae susceptibility to ciprofloxacin. It is unknown whether concurrent infections at different anatomic sites harbor different susceptibility profiles. We found a 3.2% frequency of discordant gyrase A genotypes among concurrent but anatomically separate N. gonorrhoeae infections diagnosed at 2 laboratories in Los Angeles.
We determined the frequency of discordant gyrase A genotypes among concurrent but anatomically separate Neisseria gonorrhoeae infections.
From the *David Geffen School of Medicine,
†Department of Environmental Health Sciences, Fielding School of Public Health,
‡Department of Laboratory Medicine, David Geffen School of Medicine, University of California;
§Los Angeles Lesbian Gay Bisexual and Transgender Center, Los Angels, CA;
¶Accelerate Diagnostics, Tucson, AZ;
∥Social and Scientific Systems, Inc., Silver Spring, MD,
**AIDS Healthcare Foundation;
††Division of Infectious Diseases, David Geffen School of Medicine; and
‡‡Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA
Acknowledgements: This research was supported by the National Institutes of Health, grants: R21AI77256 and R21AI109005. The authors would also like to acknowledge Nicole Green and the NG GyrA Study group for their contributions to this project.
Conflicts of Interest: None declared.
Alternative Author Information: J.D.K., Department of Medicine, Infectious Diseases, 10833 Le Conte Ave, Los Angeles, CA 90095. E-mail: firstname.lastname@example.org
Correspondence: Lao-Tzu Allan-Blitz, MD, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095. E-mail: email@example.com.
Received for publication May 30, 2018, and accepted August 31, 2018.