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The Frequency of Discordant Gyrase A Genotypes Among Cases of Multiple Neisseria gonorrhoeae Infections at Different Anatomic Sites

Allan-Blitz, Lao-Tzu, MD*; Ellis, Olivia L., MS, MPH†‡; Bolan, Robert, MD§; Hemarajata, Peera, MD, PhD; Humphries, Romney M., PhD‡¶; Shahkolahi, Akbar, MD; McGrath, Mark, MD**; Klausner, Jeffrey D., MD, MPH††‡‡

Sexually Transmitted Diseases: January 2019 - Volume 46 - Issue 1 - p e3–e4
doi: 10.1097/OLQ.0000000000000912
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Gyrase A genotyping reliably predicts Neisseria gonorrhoeae susceptibility to ciprofloxacin. It is unknown whether concurrent infections at different anatomic sites harbor different susceptibility profiles. We found a 3.2% frequency of discordant gyrase A genotypes among concurrent but anatomically separate N. gonorrhoeae infections diagnosed at 2 laboratories in Los Angeles.

We determined the frequency of discordant gyrase A genotypes among concurrent but anatomically separate Neisseria gonorrhoeae infections.

From the *David Geffen School of Medicine,

Department of Environmental Health Sciences, Fielding School of Public Health,

Department of Laboratory Medicine, David Geffen School of Medicine, University of California;

§Los Angeles Lesbian Gay Bisexual and Transgender Center, Los Angels, CA;

Accelerate Diagnostics, Tucson, AZ;

Social and Scientific Systems, Inc., Silver Spring, MD,

**AIDS Healthcare Foundation;

††Division of Infectious Diseases, David Geffen School of Medicine; and

‡‡Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA

Acknowledgements: This research was supported by the National Institutes of Health, grants: R21AI77256 and R21AI109005. The authors would also like to acknowledge Nicole Green and the NG GyrA Study group for their contributions to this project.

Conflicts of Interest: None declared.

Alternative Author Information: J.D.K., Department of Medicine, Infectious Diseases, 10833 Le Conte Ave, Los Angeles, CA 90095. E-mail: jdklausner@mednet.ucla.edu

Correspondence: Lao-Tzu Allan-Blitz, MD, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095. E-mail: lao.allanblitz@gmail.com.

Received for publication May 30, 2018, and accepted August 31, 2018.

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