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Preexposure Prophylaxis for Human Immunodeficiency Virus (HIV) Prevention Among HIV–uninfected Pregnant Women

Estimated Coverage Using Risk-based Versus Regional Prevalence Approaches

Pintye, Jillian, PhD*; Singa, Benson, MD; Wanyonyi, Kennedy, BS; Itindi, Janet, BS; Kinuthia, John, MD; Langat, Agnes, MD§; Nganga, Lucy, MD§; Katana, Abraham, MD§; Baeten, Jared M., MD, PhD; McGrath, Christine J., PhD*; John-Stewart, Grace, MD, PhD

doi: 10.1097/OLQ.0000000000000898

Antenatal register data from 62 clinics in 5 regions of Kenya were used to estimate women with human immunodeficiency virus (HIV) risk (partner HIV status, syphilis). With individual risk-guided preexposure prophylaxis (PrEP) offer in all regions, 39% of pregnant women would be offered PrEP nationally. Offering PrEP to all women in high-prevalence regions reached 26% of the pregnant women.

We estimated the proportion of pregnant women nationally who would be offered preexposure prophylaxis with risk-guided or prevalence-guided approaches in Kenya.

From the *Department of Global Health, University of Washington, Seattle, WA;

Kenya Medical Research Institute;

Kenyatta National Hospital;

§Centers for Disease Control and Prevention (CDC) Kenya, Nairobi, Kenya; and

Departments of Epidemiology and Medicine, University of Washington, Seattle, WA

Sources of Funding: President’s Emergency Plan for AIDS Relief (PEPFAR) and Centers for Disease Control and Prevention (COAG#U2GPS002047). JP was supported by a NIH training grant T32AI07140 and F32NR017125. GJS was supported by an NIH K24 grant (HD054314). The CHIME Team was supported by the University of Washington’s Global Center for Integrated Health of Women Adolescents and Children (Global WACh) and Center for AIDS Research (CFAR) (P30 AI027757).

CDC Disclaimer: The findings and conclusions in this paper are those of the author(s) and do not necessarily represent the official position of the U.S. Centers for Disease Control and Prevention, United States National Institutes of Health and Government of Kenya.

Correspondence: Jillian Pintye, PhD; University of Washington, Department of Global0020Health, 325 Ninth Ave., Box 359909, Seattle, WA 98104. E-mail:

Received for publication May 14, 2018, and accepted July 15, 2018.

© Copyright 2018 American Sexually Transmitted Diseases Association